Results 41 to 50 of about 5,940 (176)

A Limited Association of OGG1 Ser326Cys Polymorphism for Adenocarcinoma of the Lung.

Journal of Epidemiology, 2002
The 8-oxoguanine DNA glycosylase (OGG1) repairs DNA by removing 8-hydroxyguanine, a highly mutagenic oxidative DNA adduct. Recently, the gene for OGG1 was cloned and several polymorphisms have been reported. Because environmental carcinogens produce 8-hydroxyguanine residues that potentially cause oncogenic mutations by mismatching to this modified ...
Ito, Hidemi, Hamajima, Nobuyuki, Takezaki, Toshiro, Matsuo, Keitaro, Tajima, Kazuo, Tajima, Kazuo, Hatooka, Shunzo, Mitsudomi, Tetsuya, Suyama, Motokazu, Sato, Shigeki, Ueda, Ryuzo   +10 more
openaire   +3 more sources

OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis

Biomedicines, 2022
Acute pancreatitis (AP) is a potentially life-threatening gastrointestinal disease with a complex pathology including oxidative stress. Oxidative stress triggers oxidative DNA lesions such as formation of 7,8-dihydro-8-oxo-2′-oxoguanine (8-oxoG) and also
Zoltán Hajnády, Máté Nagy-Pénzes, Máté A. Demény, Katalin Kovács, Tarek El-Hamoly, József Maléth, Péter Hegyi, Zsuzsanna Polgár, Csaba Hegedűs, László Virág   +9 more
doaj   +1 more source

Comparison of OGG1 gene expression level in gastric adenocarcinoma and adjacent normal tissue [PDF]

فصلنامه ابن سینا, 2021
Background and aims: Gastric cancer is a major public health issue as the fourth leading cause of cancer-related death in the world. Reactive oxygen species (ROS) induce DNA damage and this process plays an important role in gastric cancer development ...
Somayyeh Moosaie, Zeynab Afshari, Abdollah Abbasi, Manuchehr Ghojaie, Arezoo Farhadi, Mohammad Foad Heidari, Shirin Shahbazi, Javad Behroozi, Mehrdad Nasrollahzadeh Sabet   +8 more
doaj  

Complex Roles of NEIL1 and OGG1: Insights Gained from Murine Knockouts and Human Polymorphic Variants

DNA, 2022
DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both the nuclear and mitochondrial genomes. Several of these enzymes have overlapping substrate recognition, through which a degree of redundancy in lesion recognition
R. Stephen Lloyd
doaj   +1 more source

Polymorphisms in DNA repair genes increase the risk for type 2 diabetes mellitus and hypertension

Biomolecular Concepts, 2018
We investigated the effect of polymorphisms in four DNA repair genes, viz. RAD18 Arg302Gln (G>A) (rs373572), XPD Asp312Asn (G>A) (rs1799793), APE1 Asp148Glu (T>G) (rs3136820), and OGG1 Ser326Cys (C>G) (rs1052133) on the risk for type 2 diabetes mellitus (
Das Sambuddha, Purkayastha Sukanya, Roy Hirakjyoti, Sinha Anima, Choudhury Yashmin   +4 more
doaj   +1 more source

Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes

BMC Endocrine Disorders, 2002
Background It has become increasingly clear that β-cell failure plays a critical role in the pathogenesis of type 2 diabetes. Free-radical mediated β-cell damage has been intensively studied in type 1 diabetes, but not in human type 2 diabetes. Therefore,
Yoon Kun-Ho, Wang-Rodriguez Jessica, Dib Sergio A, Anachkov Kamen A, Tyrberg Björn, Levine Fred   +5 more
doaj   +1 more source

Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors

Molecular Cancer, 2008
Background Tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors. Loss of heterozygosity (LOH) at the TSC2 locus has
Habib Samy L, Simone Simona, Barnes Jeff J, Abboud Hanna E   +3 more
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Roles of OGG1 in transcriptional regulation and maintenance of metabolic homeostasis

DNA Repair, 2019
Cellular damage produced by conditions generating oxidative stress have far-reaching implications in human disease that encompass, but are not restricted to aging, cardiovascular disease, type 2 diabetes, airway inflammation/asthma, cancer, and metabolic syndrome including visceral obesity, insulin resistance, fatty liver disease, and dyslipidemia ...
Harini, Sampath, R Stephen, Lloyd
openaire   +3 more sources

The Role of DNA Repair Glycosylase OGG1 in Intrahepatic Cholangiocarcinoma [PDF]

Anticancer Research, 2019
The effects of oxidative stress on various carcinomas were reported in previous studies, but those in intrahepatic cholangiocarcinoma (ICC) have not been fully elucidated. The purpose of this study was, thus, to reveal the effects of oxidative DNA damage and repair enzymes on ICC.The levels of 8-hydroxydeoxyguanosine (8-OHdG) and 8-OHdG DNA glycosylase
Kazuhito, Sakata, Tomoharu, Yoshizumi, Takuma, Izumi, Masahiro, Shimokawa, Shinji, Itoh, Toru, Ikegami, Noboru, Harada, Takeo, Toshima, Yohei, Mano, Masaki, Mori   +9 more
openaire   +2 more sources