Results 21 to 30 of about 5,940 (176)

Long-term pulmonary complications in sulfur mustard-exposed patients: gene expression and DNA methylation of OGG1 [PDF]

BioImpacts
Introduction: It is well established that tissues exposed to sulfur mustard (SM) generate high levels of reactive oxygen species. This leads to oxidative stress and, ultimately, damage to DNA molecules over the course of time.
Mohammad Saber Zamani, Tooba Ghazanfari
doaj   +1 more source

Altered Epigenetic Marks and Gene Expression in Fetal Brain, and Postnatal Behavioural Disorders, Following Prenatal Exposure of Ogg1 Knockout Mice to Saline or Ethanol

Cells, 2023
Oxoguanine glycosylase 1 (OGG1) is widely known to repair the reactive oxygen species (ROS)-initiated DNA lesion 8-oxoguanine (8-oxoG), and more recently was shown to act as an epigenetic modifier.
Shama Bhatia, David Bodenstein, Ashley P. Cheng, Peter G. Wells   +3 more
doaj   +1 more source

Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1 [PDF]

ACS Chemical Biology, 2019
Oxidative damage in DNA is one of the primary sources of mutations in the cell. The activities of repair enzymes 8-oxoguanine DNA glycosylase (OGG1) and human MutT Homologue 1 (NUDT1 or MTH1), which work together to ameliorate this damage, are closely linked to mutagenesis, genotoxicity, cancer, and inflammation. Here we have undertaken the development
Yu-ki Tahara, Anna M. Kietrys, Marian Hebenbrock, Yujeong Lee, David L. Wilson, Eric T. Kool   +5 more
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Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1

Frontiers in Immunology, 2023
Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections.
Yaoyao Xue, Yaoyao Xue, Lang Pan, Spiros Vlahopoulos, Ke Wang, Ke Wang, Xu Zheng, Xu Zheng, Zsolt Radak, Attila Bacsi, Lloyd Tanner, Allan R. Brasier, Xueqing Ba, Istvan Boldogh   +13 more
doaj   +1 more source

OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2008
Oxidative DNA damage is believed to be implicated in lung carcinogenesis. 8-OxodG is a mutagenic and abundant oxidative modification induced in DNA. OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress.
Hatt, Lotte, Loft, Steffen, Risom, Lotte, Møller, Peter, Sørensen, Mette, Raaschou-Nielsen, Ole, Overvad, Kim, Tjønneland, Anne, Vogel, Ulla   +8 more
openaire   +4 more sources

Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis [PDF]

International Journal of Molecular Sciences, 2017
The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2’-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice. A total of 80 male and female six-week-old mice of C57BL/6J background carrying a mutant Mmh allele of the Mmh/Ogg1 gene (Ogg1−/−) and ...
Kakehashi, Anna, Ishii, Naomi, Okuno, Takahiro, Fujioka, Masaki, Gi, Min, Wanibuchi, Hideki   +5 more
openaire   +2 more sources

Investigation of APE1 and OGG1 expression in chronic hemodialysis patients

Molecular Biology Reports, 2023
Abstract Background: The role of DNA repair mechanisms is of significant importance in diseases characterized by elevated oxidative DNA damage, such as chronic kidney disease. It is imperative to thoroughly understand the functions of molecules associated with DNA repair mechanisms, not only for assessing susceptibility to diseases but also for
Rostami M., Yalin S.F., Altiparmak M.R., Guven M.   +3 more
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8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle. [PDF]

PLoS ONE, 2017
Oxidative stress resulting from endogenous and exogenous sources causes damage to cellular components, including genomic and mitochondrial DNA. Oxidative DNA damage is primarily repaired via the base excision repair pathway that is initiated by DNA ...
Vladimir Vartanian, Jana Tumova, Pawel Dobrzyn, Agnieszka Dobrzyn, Yusaku Nakabeppu, R Stephen Lloyd, Harini Sampath   +6 more
doaj   +1 more source

Carcinogenicity of dimethylarsinic acid in Ogg1‐deficient mice [PDF]

Cancer Science, 2007
Oxidative stress to DNA is recognized as a mechanism underlying carcinogenic effects of some environmental agents. Here, we hypothesized that dimethylarsinic acid (DMAV), an organic metabolite of inorganic arsenic in humans, might exert carcinogenic potential in a mouse line carrying a mutant Mmh allele of the Mmh/OGG1 gene encoding the enzyme 8 ...
Anna, Kinoshita, Hideki, Wanibuchi, Keiichirou, Morimura, Min, Wei, Dai, Nakae, Tsuyoshi, Arai, Osamu, Minowa, Tetsuo, Noda, Susumu, Nishimura, Shoji, Fukushima   +9 more
openaire   +2 more sources

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

Redox Biology, 2018
8-Oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair pathway by removing one of the most abundant DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). Recent data showed that 8-oxoG not only is a pro-mutagenic genomic base lesion, but also
Wenjing Hao, Tianyang Qi, Lang Pan, Ruoxi Wang, Bing Zhu, Leopoldo Aguilera-Aguirre, Zsolt Radak, Tapas K. Hazra, Spiros A. Vlahopoulos, Attila Bacsi, Allan R. Brasier, Xueqing Ba, Istvan Boldogh   +12 more
doaj   +1 more source