Results 61 to 70 of about 1,564,144 (179)
Environmental Toxicology and Chemistry, EarlyView.Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff +2 more
wiley +1 more source
N-Glycosyl Bond Formation Catalyzed by Human Alkyladenine DNA Glycosylase
, 2016 The removal of damaged bases by DNA glycosylases is thought to be effectively irreversible, because of an overall equilibrium that favors hydrolysis over synthesis of the N-glycosyl bond.
Suzanne J. Admiraal (2257027) +1 more
core +1 more source
Crystal structure of mimivirus uracil-DNA glycosylase. [PDF]
PLoS ONE, 2017 Cytosine deamination induced by stresses or enzymatic catalysis converts deoxycytidine into deoxyuridine, thereby introducing a G to A mutation after DNA replication.
Eunju Kwon +3 more
doaj +1 more source
DNA N-glycosylase deficient mice:a tale of redundancy
, 2003 The generation of mouse models of base excision repair deficiency has resulted in a re-examination of the cellular defence mechanisms that exist to counteract oxidative base damage.
Elder, RH +3 more
core +1 more source
Bacillus Calmette-Guerin Increases Base Excision Repair in Bladder Cancer Cells
Journal of Urological Surgery, 2021 Objective:Most patients with non-muscle-invasive bladder cancer (NMIBC) do not respond to intravesical Bacillus Calmette-Guerin (BCG) immunotherapy and have high risk of NMIBC recurrence and progression.
Selçuk Keskin +2 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Biochemical reconstitution of heat-induced mutational processes.
PLoS ONENon-enzymatic spontaneous deamination of 5-methylcytosine, producing thymine, is the proposed etiology of cancer mutational signature 1, which is the most predominant signature in all cancers. Here, the proposed mutational process was reconstituted using
Tomohiko Sugiyama
doaj +1 more source
Scientific Reports, 2017 Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional uracil DNA glycosylase (SMUG1).
Lene Alsøe +15 more
doaj +1 more source
Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy +7 more
wiley +1 more source
Electrochemistry Communications, 2019 Human 8-oxoguanine DNA glycosylase 1 (hOGG1) is an important DNA repair enzyme, which is closely related to the occurrence and development of certain diseases.
Dawei Yang +3 more
doaj +1 more source