Results 71 to 80 of about 43,780 (231)

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG) [PDF]

, 2009
The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N[superscript 6]-ethenoadenine (εA).
Aas P. A., Abner C. W., Adhikari S., Berti P. J., Bjelland S., Chakravarti D., Delaney J. C., Delaney J. C., Dianov G., Dosanjh M. K., Eftedal I., el Ghissassi F., Elder R. H., Engelward B. P., Falnes P. O., Falnes P. O., Falnes P. O., Frick L. E., Friedberg E. C., Gallagher P. E., Goodenough A. K., Guengerich F. P., Guengerich F. P., Guengerich F. P., Guliaev A. B., Hang B., Haushalter K. A., Hitchcock T. M., Koivisto P., Kusmierek J. T., Kusmierek J. T., Lau A. Y., Lau A. Y., Leonard N. J., Ludlum D. B., Miao F., Mishina Y., Nilsen H., Ougland R., O’Brien P. J., O’Brien P. J., O’Connor T. R., O’Connor T. R., O’Neill R. J., Pearl L. H., Pendlebury A., Ringvoll J., Roy R., Samson L., Saparbaev M., Saparbaev M., Saparbaev M., Singer B., Trewick S. C., Wang H., Westbye M. P., Wuenschell G. E., Wyatt M. D.   +57 more
core   +1 more source

A novel uracil-DNA glycosylase family related to the helix-hairpin-helix DNA glycosylase superfamily [PDF]

Nucleic Acids Research, 2003
Cytosine bases can be deaminated spontaneously to uracil, causing DNA damage. Uracil-DNA glycosylase (UDG), a ubiquitous uracil-excising enzyme found in bacteria and eukaryotes, is one of the enzymes that repair this kind of DNA damage. To date, no UDG-coding gene has been identified in Methanococcus jannaschii, although its entire genome was ...
Ji Hyung, Chung, Eun Kyoung, Im, Hyun-Young, Park, Jun Hye, Kwon, Seahyoung, Lee, Jaewon, Oh, Ki-Chul, Hwang, Jong Ho, Lee, Yangsoo, Jang   +8 more
openaire   +2 more sources

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]

, 2016
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Aedo, Afonine, Amundsen, Amundsen, Bannister, Baños-Sanz, Cano, Cirz, CLSI, Cole, Court, Court, Cronan, Darrigo, Datta, Dillingham, Emsley, Forage, González-Soltero, Henderson, Kennaway, Kulkarni, Li, Liu, Liu, López, McDaniel, Murphy, Murphy, Murphy, Muyrers, Paczosa, Pettersen, Robinson, Sakaki, Scheres, Singleton, Tamae, Urnavicius, Wang, Wiegand, Wigley, Wilkinson, Zhang, Zhang   +44 more
core   +5 more sources

Detection of Damaged DNA Bases by DNA Glycosylase Enzymes [PDF]

Biochemistry, 2010
A fundamental and shared process in all forms of life is the use of DNA glycosylase enzymes to excise rare damaged bases from genomic DNA. Without such enzymes, the highly ordered primary sequences of genes would rapidly deteriorate. Recent structural and biophysical studies are beginning to reveal a fascinating multistep mechanism for damaged base ...
Joshua I, Friedman, James T, Stivers
openaire   +2 more sources

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

PERFUME: detection of 8-oxoguanine DNA glycosylase activity based on primer exchange reaction and functionalized hemin/G-quadruplex DNAzyme

Talanta Open
Background: 8-oxoguanine DNA glycosylase can maintain genomic stability and integrity. However, it can interfere with the regular DNA damage repair process, possibly leading to the development of cancer and various other human diseases when its activity ...
Kaiting Xiao, Yanming Lai, Xingxing Liu, Shengjie Li, Wenxu Yuan, Ziyun Wang, Pan Pan, Yongkui Li, Heng Xiao   +8 more
doaj   +1 more source

Stable transgenerational epigenetic inheritance requires a DNA methylation-sensing circuit

Nature Communications, 2017
DNA methylation patterns are inherited over many generations in plants. Here, Williams and Gehring show that the 5-methylcytosine DNA glycosylase ROS1 functions as part of a methylation-sensitive circuit that ensures long-term epigenetic fidelity in ...
Ben P. Williams, Mary Gehring
doaj   +1 more source

Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases [PDF]

DNA Repair, 2009
Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three-dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg proteins recognizing formamidopyrimidines, 8-oxoguanine (8-oxoG) and its oxidation products ...
Scott D, Kathe, Ramiro, Barrantes-Reynolds, Pawel, Jaruga, Michael R, Newton, Cynthia J, Burrows, Viswanath, Bandaru, Miral, Dizdaroglu, Jeffrey P, Bond, Susan S, Wallace   +8 more
openaire   +2 more sources