Results 71 to 80 of about 2,011,431 (260)

A universal framework to efficiently share material and process resources in the DNA construction world [PDF]

arXiv, 2021
DNA constructs and their annotated sequence maps have been rapidly accumulating with the advancement of DNA cloning, synthesis, and assembly methods. Such a resource has the potential to be optimally utilized in an autonomous DNA building platform. However, most DNA design processes today remain manually operated with the assistance of graphical user ...
arxiv  

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update

Cancer Communications, Volume 45, Issue 3, Page 332-379, March 2025.
Abstract The 2024 updates of the Chinese Society of Clinical Oncology (CSCO) Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China, highlighting the latest advancements in evidence‐based medicine, healthcare resource access, and precision medicine in oncology.
Feng Wang, Gong Chen, Zhen Zhang, Ying Yuan, Yi Wang, Yuan‐Hong Gao, Weiqi Sheng, Zixian Wang, Xinxiang Li, Xianglin Yuan, Sanjun Cai, Li Ren, Yunpeng Liu, Jianmin Xu, Yanqiao Zhang, Houjie Liang, Xicheng Wang, Aiping Zhou, Jianming Ying, Guichao Li, Muyan Cai, Gang Ji, Taiyuan Li, Jingyu Wang, Hanguang Hu, Kejun Nan, Liuhong Wang, Suzhan Zhang, Jin Li, Rui‐Hua Xu   +29 more
wiley   +1 more source

Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase. [PDF]

PLoS ONE, 2016
Trypanosoma cruzi, the etiological agent of Chagas' disease, presents three cellular forms (trypomastigotes, epimastigotes and amastigotes), all of which are submitted to oxidative species in its hosts. However, T.
Fernando Ormeño, Camila Barrientos, Santiago Ramirez, Iván Ponce, Lucía Valenzuela, Sofía Sepúlveda, Mainá Bitar, Ulrike Kemmerling, Carlos Renato Machado, Gonzalo Cabrera, Norbel Galanti   +10 more
doaj   +1 more source

Life without dUTPase [PDF]

arXiv, 2015
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of DNA. The genetic information is also safeguarded by DNA damage recognition and repair processes. Uracil is one of the most frequently occurring erroneous base in DNA; it can arise from cytosine deamination or thymine-replacing incorporation.
arxiv  

Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis

Cancer Communications, Volume 45, Issue 3, Page 245-280, March 2025.
Abstract Background Adaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl‐CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have recently been highlighted.
Zhicong Chen, Yanqing Gong, Fukai Chen, Hyeon Jeong Lee, Jinqin Qian, Jing Zhao, Wenpeng Zhang, Yamin Li, Yihui Zhou, Qiaobing Xu, Yu Xia, Liqun Zhou, Ji‐Xin Cheng   +12 more
wiley   +1 more source

Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor

Nucleic Acids Research, 2013
DNA mimic proteins are unique factors that control the DNA binding activity of target proteins by directly occupying their DNA binding sites. The extremely divergent amino acid sequences of the DNA mimics make these proteins hard to predict, and although
Hao-Ching Wang, K. Hsu, Jinn-Moon Yang, Mao-Lun Wu, T. Ko, Shen-Rong Lin, A. H. Wang   +6 more
semanticscholar   +1 more source

Impact of Helicobacter pylori Infection and Its Major Virulence Factor CagA on DNA Damage Repair

Microorganisms, 2020
Helicobacter pylori infection induces a plethora of DNA damages. Gastric epithelial cells, in order to maintain genomic integrity, require an integrous DNA damage repair (DDR) machinery, which, however, is reported to be modulated by the infection.
Eleftherios Kontizas, Spyros Tastsoglou, Timokratis Karamitros, Yiannis Karayiannis, Panagoula Kollia, Artemis G. Hatzigeorgiou, Dionyssios N. Sgouras   +6 more
doaj   +1 more source

Monte Carlo simulation of melting transition on DNA nanocompartment [PDF]

, 2005
DNA nanocompartment is a typical DNA-based machine whose function is dependent of molecular collective effect. Fundamental properties of the device have been addressed via electrochemical analysis, fluorescent microscopy, and atomic force microscopy. Interesting and novel phenomena emerged during the switching of the device.
arxiv   +1 more source

Mitochondria‐Targeted Temozolomide Probe for Overcoming MGMT‐Mediated Resistance in Glioblastoma

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
Mitochondria‐targeted temozolomide (mtTmz) using peptide‐based delivery vector has been shown to overcome direct DNA repair and resistance by O6‐methylgunaine DNA methyltransferase (MGMT) in glioblastoma (GBM) cells. This has been demonstrated through viability assays using MGMT‐positive and negative cell lines, and the effect of mtTmz on MGMT ...
Daniel Szames, Shana O. Kelley
wiley   +1 more source

Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.

Biochemical Journal, 2013
TDG (thymine DNA glycosylase) is an essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation and transcription regulation.
A. Madabushi, Bor‐Jang Hwang, Jin Jin, A. Lu   +3 more
semanticscholar   +1 more source