Results 111 to 120 of about 20,880 (290)

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney [PDF]

, 2014
Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA ...
Abolhassani, Nona, Allocca, Mariacarmela, Ayata, Cenk, Calvo, Jennifer A., Daneshmand, Ali, Ebrahimkhani, Mohammad Reza, Jhun, Iny, Mazumder, Aprotim, Muthupalani, Sureshkumar, Samson, Leona D   +9 more
core   +1 more source

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function

Chemistry – A European Journal, EarlyView.
Organocatalytic switches are small molecules that combine active site affinity and a nitrogen‐centered base for catalysis, effectively removing the rate‐determining step of the OGG1 biochemical cascade. Here, we identify a minimal structure and modulate the active nitrogen pKa, enabling the catalysis of ultrafast AP site incisions in a range of pH ...
Mario Kehler, Kaixin Zhou, Aurino M. Kemas, Alicia del Prado, Emma Scaletti Hutchinson, Elinor Hesslefors Nairn, Marek Varga, Yvonne Plattner, Yi Zhong, Oryn Purewal‐Sidhu, James Haslam, Elisée Wiita, Heather Gildie, Karolina Singerova, Zuzanna Szaruga, Ingrid Almlöf, Femke M. Hormann, Kang‐Cheng Liu, Olov Wallner, Florian Ortis, Evert J. Homan, Opher Gileadi, Sean G. Rudd, Pål Stenmark, Miguel de Vega, Thomas Helleday, Nicholas D. D'Arcy‐Evans, Volker M. Lauschke, Maurice Michel   +28 more
wiley   +1 more source

Cell transformation in tumor-development: a result of accumulation of Misrepairs of DNA through many generations of cells [PDF]

arXiv, 2015
Development of a tumor is known to be a result of accumulation of DNA changes in somatic cells. However, the processes of how DNA changes are produced and how they accumulate in somatic cells are not clear. DNA changes include two types: point DNA mutations and chromosome changes.
arxiv  

DNA-Correcting Codes in DNA Storage Systems [PDF]

arXiv, 2023
In [1], the authors proposed a new model of DNA storage system that integrates all three steps of retrieval and introduced the concept of DNA-correcting codes, which guarantees that the output of the storage system can be decoded to the original data. They also gave necessary and sufficient conditions for DNA-correcting codes when the data part is free
arxiv  

Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase [PDF]

DNA Repair, 2005
To investigate the role of Arginine 276 in the conserved leucine-loop of human uracil-DNA glycosylase (UNG), the effects of six R276 amino acid substitutions (C, E, H, L, W, and Y) on nucleotide flipping and enzyme conformational change were determined using transient and steady state, fluorescence-based, kinetic analysis.
Cheng Yao Chen, Dale W. Mosbaugh, Samuel E. Bennett   +2 more
openaire   +2 more sources

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Approaches to Detection of Distantly Related Proteins by Database Searches

BioTechniques, 1996
The searching of protein databases as a method of identifying newly sequenced genes is commonplace in molecular biology laboratories. However, it is a procedure that is not usually formally taught to students, and method cookbooks discuss it only briefly.
K. Cattell, B. Koop, R.S. Olafson, M. Fellows, I. Bailey, R.W. Olafson, C. Upton   +6 more
doaj   +1 more source

DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. [PDF]

PLoS ONE, 2010
Base excision repair (BER) is a DNA repair pathway designed to correct small base lesions in genomic DNA. While DNA polymerase beta (pol beta) is known to be the main polymerase in the BER pathway, various studies have implicated other DNA polymerases in
Elena K Braithwaite, Padmini S Kedar, Deborah J Stumpo, Barbara Bertocci, Jonathan H Freedman, Leona D Samson, Samuel H Wilson   +6 more
doaj   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

The combined role of NTH and MUTY DNA glycosylases in mycobacterium smegmatis [PDF]

, 2016
A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Medicine.During infection, Mycobacterium tuberculosis (MTB) encounters ...
Nthambeleni, Gadisi
core