DNA glycosylases provide antiviral defence in prokaryotes. [PDF]
NatureBacteria have adapted to phage predation by evolving a vast assortment of defence systems1. Although anti-phage immunity genes can be identified using bioinformatic tools, the discovery of novel systems is restricted to the available prokaryotic sequence
Hossain AA +10 more
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Focus on DNA Glycosylases-A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets. [PDF]
Int J Mol Sci, 2020 Cancer is the second leading cause of death with tens of millions of people diagnosed with cancer every year around the world. Most radio- and chemotherapies aim to eliminate cancer cells, notably by causing severe damage to the DNA.
Hans F +3 more
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Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases [PDF]
Cells, 2021 It was proposed that the last universal common ancestor (LUCA) evolved under high temperatures in an oxygen-free environment, similar to those found in deep-sea vents and on volcanic slopes.
Paulina Prorok +6 more
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DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition [PDF]
Cellular and Molecular Life SciencesBase excision repair, initiated by DNA glycosylases, preserves genomic integrity by removing damaged bases. DNA glycosylases Ogg1 and Mutyh were shown to alter the hippocampal transcriptome independently of DNA damage repair.
Andreas Abentung +7 more
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Inhibition of DNA glycosylases via small molecule purine analogs. [PDF]
PLoS ONE, 2013 Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed.
Aaron C Jacobs +9 more
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Active DNA demethylation mediated by DNA glycosylases. [PDF]
Annual Review of Genetics, 2009 Active DNA demethylation is involved in many vital developmental and physiological processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis have demonstrated that a subfamily of DNA glycosylases function to promote DNA demethylation through a base excision-repair pathway.
Jian‐Kang Zhu
semanticscholar +3 more sources
Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea [PDF]
Frontiers in Microbiology, 2021 Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Tan Lin +6 more
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Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases [PDF]
mBio, 2022 Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs).
Noah P. Bradley +4 more
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DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. [PDF]
PLoS Genetics, 2014 Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Ana Osorio +199 more
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The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. [PDF]
Sci Rep, 2017 Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked psoralen-
Martin PR +9 more
europepmc +2 more sources