Results 11 to 20 of about 20,880 (290)

Geminiviruses employ host DNA glycosylases to subvert DNA methylation-mediated defense. [PDF]

Nat Commun, 2022
Plants tightly regulate DNA methylation to regulate gene expression. Here, the authors show that the tomato yellow leaf curl China virus βC1 protein interacts with plant DNA glycosylases to promote demethylation of viral DNA and promote virulence.
Gui X, Liu C, Qi Y, Zhou X.
europepmc   +2 more sources

Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases. [PDF]

Cells, 2022
Proteins that recognize specific DNA sequences or structural elements often find their cognate DNA lesions in a processive mode, in which an enzyme binds DNA non-specifically and then slides along the DNA contour by one-dimensional diffusion. Opposite to
Diatlova EA, Mechetin GV, Zharkov DO.
europepmc   +2 more sources

Evolutionary Origins of DNA Repair Pathways: Role of Oxygen Catastrophe in the Emergence of DNA Glycosylases. [PDF]

Cells, 2021
It was proposed that the last universal common ancestor (LUCA) evolved under high temperatures in an oxygen-free environment, similar to those found in deep-sea vents and on volcanic slopes.
Prorok P, Grin IR, Matkarimov BT, Ishchenko AA, Laval J, Zharkov DO, Saparbaev M.   +6 more
europepmc   +2 more sources

NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. [PDF]

Commun Biol, 2021
Gunn Hildrestrand, Veslemøy Rolseth, and Nicolas Kunath et al. examine mice lacking the NEIL1 and NEIL2 DNA glycosylases involved in base excision repair.
Hildrestrand GA, Rolseth V, Kunath N, Suganthan R, Jensen V, Bugaj AM, Fernandez-Berrocal MS, Sikko SB, Vetlesen S, Kuśnierczyk A, Olsen AK, Gützkow KB, Rowe AD, Wang W, Moldestad O, Syrstad MD, Slupphaug G, Eide L, Klungland A, Sætrom P, Luna L, Ye J, Scheffler K, Bjørås M.   +23 more
europepmc   +2 more sources

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea. [PDF]

Front Microbiol, 2021
Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge.
Lin T, Zhang L, Wu M, Jiang D, Li Z, Yang Z.   +5 more
europepmc   +2 more sources

Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases. [PDF]

mBio, 2022
Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs).
Bradley NP, Wahl KL, Steenwyk JL, Rokas A, Eichman BF.   +4 more
europepmc   +2 more sources

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. [PDF]

Elife, 2019
Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.
Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A, Niehrs C.   +8 more
europepmc   +2 more sources

No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. [PDF]

Sci Rep, 2017
Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of
Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M.   +14 more
europepmc   +2 more sources

Conformational Dynamics of Biopolymers in the Course of Their Interaction: Multifaceted Approaches to the Analysis by the Stopped-Flow Technique with Fluorescence Detection

Photonics, 2023
This review deals with modern approaches to systematic research on molecular-kinetic mechanisms of damage recognition and removal by pro- and eukaryotic enzymes of DNA base excision repair.
Nikita A. Kuznetsov
doaj   +1 more source

Potent pollen gene regulation by DNA glycosylases in maize. [PDF]

Nat Commun
Although DNA methylation primarily represses TEs, it also represses select genes that are methylated in plant body tissues but demethylated by DNA glycosylases (DNGs) in endosperm or pollen.
Zeng Y, Somers J, Bell HS, Vejlupkova Z, Kelly Dawe R, Fowler JE, Nelms B, Gent JI.   +7 more
europepmc   +2 more sources