Results 51 to 60 of about 2,038,987 (238)
Expression patterns of
BMC Neuroscience, 2009 Background The base excision repair pathway is responsible for repairing small DNA base lesions caused by endogenous and exogenous damaging agents. Repair is initiated by DNA glycosylases that recognize and remove the lesions.
Bjørås Magnar +6 more
doaj +1 more source
Chemical Science, 2017 We demonstrate the simultaneous detection of human 8-oxoguanine DNA glycosylase 1 and human alkyladenine DNA glycosylase at the single-molecule level.
Juan Hu +4 more
semanticscholar +1 more source
Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference. [PDF]
PLoS ONE, 2014 Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases 8-oxo-guanine DNA glycosylase (OGG1) and mutY homolog (MYH) as well as DNA polymerase beta (Polβ ...
Geoffrey R Bennett +7 more
doaj +1 more source
Epigenetics, 2017 DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication ...
Jara Teresa Parrilla-Doblas +2 more
doaj +1 more source
The Double Face of Base Excision Repair: Preventing and Triggering Double-Strand Breaks. [PDF]
BioessaysBase excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Gasser SM.
europepmc +2 more sources
Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability
Nucleic Acids Research, 2016 DNA trinucleotide repeat (TNR) expansion underlies several neurodegenerative disorders including Huntington's disease (HD). Accumulation of oxidized DNA bases and their inefficient processing by base excision repair (BER) are among the factors suggested ...
P. Cilli +7 more
semanticscholar +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Recombinant protein expression in heterologous biological systems is an expanding field in synthetic biology. Photosynthetic organisms have the potential to provide an efficient low‐cost platform for recombinant protein production because they require minimal growth nutrients and are less susceptible to zoonotic and other contaminants ...
Bharat Kumar Majhi, Anastasios Melis
wiley +1 more source
Chemistry – A European Journal, EarlyView.G‐quadruplex (G4) folding in DNA is inhibitory to AP endonuclease, although the protein still binds well to G4s. Curiously, partially folded G‐rich sequences, possibly transient hairpins, containing AP are very good substrates for cleavage by APE1. Herein, the enzyme activity and G4 folding are studied in single‐stranded vs. duplex contexts.
Brianna L. Trabucco +2 more
wiley +1 more source
Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications
Chemistry – A European Journal, EarlyView.Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley +1 more source
Chemical Biology of Mammalian DNA Repair
CHIMIA, 2001 Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj +2 more sources