Results 81 to 90 of about 20,880 (290)
Advanced Science, Volume 12, Issue 13, April 3, 2025.MutY homolog (MUTYH) protein levels are significantly decreased in the kidneys of acute kidney injury (AKI) patients. The upregulation of the E3 ligase HUWE1 mediates the degradation of MUTYH in renal tubular epithelial cells, exacerbating DNA damage in both the nucleus and mitochondria, thereby promoting AKI. Targeting the HUWE1/MUTYH pathway may be a
Yunwen Yang +10 more
wiley +1 more source
DNA, 2022 DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both the nuclear and mitochondrial genomes. Several of these enzymes have overlapping substrate recognition, through which a degree of redundancy in lesion recognition
R. Stephen Lloyd
doaj +1 more source
Self-assembling DNA-caged particles: nanoblocks for hierarchical self-assembly [PDF]
, 2008 DNA is an ideal candidate to organize matter on the nanoscale, primarily due to the specificity and complexity of DNA based interactions. Recent advances in this direction include the self-assembly of colloidal crystals using DNA grafted particles. In this article we theoretically study the self-assembly of DNA-caged particles. These nanoblocks combine
arxiv +1 more source
7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases [PDF]
, 2012 Hydroxyl radicals predominantly react with the C(8) of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells.
Couve, Sophie +5 more
core +2 more sources
Identification of Escherichia coli Mismatch-specific Uracil DNA Glycosylase as a Robust Xanthine DNA Glycosylase [PDF]
Journal of Biological Chemistry, 2010 The gene for the mismatch-specific uracil DNA glycosylase (MUG) was identified in the Escherichia coli genome as a sequence homolog of the human thymine DNA glycosylase with activity against mismatched uracil base pairs. Examination of cell extracts led us to detect a previously unknown xanthine DNA glycosylase (XDG) activity in E. coli.
Hyun-Wook Lee +4 more
openaire +3 more sources
Advanced Science, EarlyView.In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang +10 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2022 Precise genome editing of human pluripotent stem cells (hPSCs) is crucial not only for basic science but also for biomedical applications such as ex vivo stem cell therapy and genetic disease modeling.
Ju-Chan Park +7 more
doaj
Capacity of DNA Data Embedding Under Substitution Mutations [PDF]
, 2011 A number of methods have been proposed over the last decade for encoding information using deoxyribonucleic acid (DNA), giving rise to the emerging area of DNA data embedding. Since a DNA sequence is conceptually equivalent to a sequence of quaternary symbols (bases), DNA data embedding (diversely called DNA watermarking or DNA steganography) can be ...
arxiv +1 more source
DNA Charge Transport within the Cell [PDF]
, 2015 The unique characteristics of DNA charge transport (CT) have prompted an examination of roles for this chemistry within a biological context. Not only can DNA CT facilitate long-range oxidative damage of DNA, but redox-active proteins can couple to the ...
Barton, Jacqueline K. +2 more
core +1 more source
A novel uracil-DNA glycosylase family related to the helix-hairpin-helix DNA glycosylase superfamily [PDF]
Nucleic Acids Research, 2003 Cytosine bases can be deaminated spontaneously to uracil, causing DNA damage. Uracil-DNA glycosylase (UDG), a ubiquitous uracil-excising enzyme found in bacteria and eukaryotes, is one of the enzymes that repair this kind of DNA damage. To date, no UDG-coding gene has been identified in Methanococcus jannaschii, although its entire genome was ...
Hyun Young Park +8 more
openaire +3 more sources