Results 101 to 110 of about 38,912 (254)

Iron Sulfides Produced by Thermococcales: An Iron Detoxification Mechanism

Environmental Microbiology, Volume 28, Issue 1, January 2026.
Thermococcales, archaea from hydrothermal vents, promote iron sulfide precipitation, enabling survival in iron‐rich environments. Some cells become encrusted in pyrite and do not survive mineralization, while surviving cells activate metal detoxification genes. This biomineralization process allows the population to withstand toxic iron concentrations,
T. Mariotte, R. Coudray, C. Toffano‐Nioche, F. Guyot, A. Gorlas   +4 more
wiley   +1 more source

New Aminocoumarin Antibiotics Formed by a Combined Mutational and Chemoenzymatic Approach Utilizing the Carbamoyltransferase NovN [PDF]

, 2004
Five new aminocoumarin antibiotics were produced by a combined mutational and chemoenzymatic approach. For this purpose, the 3″-carbamoyltransferase NovN from the novobiocin producer Streptomyces spheroides was overexpressed in the heterologous host S ...
Xu, Hui, Heide, Lutz, Li, Shu-Ming
core   +2 more sources

Cyclothialidine Analogs, Novel DNA Gyrase Inhibitors.

The Journal of Antibiotics, 1997
DNA gyrase inhibitors, cyclothialidines B, C, D and E were isolated from four Streptomycete strains (NR 0659, NR 0660, NR 0661 and NR 0662). Their structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The absolute stereochemistry has been determined by
K, Yamaji, M, Masubuchi, F, Kawahara, Y, Nakamura, A, Nishio, S, Matsukuma, M, Fujimori, N, Nakada, J, Watanabe, T, Kamiyama   +9 more
openaire   +3 more sources

Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters

Scientific Reports, 2020
Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic treatment by entering a dormant state. The emergence of persisters from dormancy after antibiotic withdrawal leads to recurrent infection.
Ashraf Zarkan, Marta Matuszewska, Stephen B. Trigg, Meng Zhang, Daaniyah Belgami, Cameron Croft, Junyan Liu, Sawssen El-Ouisi, Jack Greenhalgh, James S. Duboff, Taufiq Rahman, David K. Summers   +11 more
doaj   +1 more source

The gyrB gene is a useful phylogenetic marker for exploring the diversity of flavobacterium strains isolated from terrestrial and aquatic habitats in Antarctica [PDF]

, 2011
Within the phylum Bacteroidetes, the gyrB gene, encoding for the B subunit of the DNA gyrase, has been used as phylogenetic marker for several genera closely related to Flavobacterium.
Peeters, Karolien, Willems, Anne
core   +1 more source

In-silico design of some tetrazoloquinoline analogs as potent inhibitors of DNA gyrase of Salmonella typhi: QSAR modeling, molecular docking, MD simulation, and ADMET profiling

In Silico Research in Biomedicine
The rising incidences of multi-drug resistance in Salmonella typhi have made the WHO to enlist the bacteria among the highest priority pathogens group that requires urgent attention.
Philip John Ameji, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba, Muhammad Tukur Ibrahim   +4 more
doaj   +1 more source

Synthesis, In silico Molecular Docking Studies and antimicrobial evaluation of Some New Anthracene Derivatives Tagged with Arylidene, Pyridine, Oxazole, and Chromene Moieties as Promising Inhibitors of Bacterial DNA gyrase

, 2022
Hemat M. Dardeer, Ahmed E. Taha, Arafat Toghan, Aboubakr H. Abdelmonsef, M Schiel, G Silbestri, M Alvarez, C Domini, R Gujjarappa, M Albratty, H Alhazmi, A Abu-Hashem, U Fathy, M Gouda, S Mishra, S Patel, C Halpani, T Orlando, P Salbego, F Farias, G Weimer, J Copetti, H Bonacorso, N Zanatta, M Hoerner, J Bern, M Martins, H Rashdan, A Abdel-Aziem, D El-Naggar, S Nabil, M Kasthuri, C Li, K Verma, O Russell, L Dickson, L Mccormick, L Bassit, F Amblard, R Schinazi, M Asif, M Imran, Abida, Y Nayak, S Gaonkar, E Saleh, H Trivedi, V Joshi, B Patel, L Turones, A Martins, L Moreira, S Da, J Fajemiroye, E Costa, A Moustafa, H El-Sayed, S El Rayes, H Morsy, S Abd-Allah, H Ismail, Abd El-Aal, M, Y Wu, Z Guo, W Deng, J Wang, Sd, S Dasari, S Tondepu, L Vadali, N Seelam, T Yakantham, R Sreenivasulu, G Alluraiah, M Tej, R Ramesh Raju, H Saadati-Moshtaghin, B Maleki, R Tayebee, S Kahrobaei, F Abbasinohoji, A Donaire-Arias, A Montagut, R Puig De La Bellacasa, R Estrada-Tejedor, J Teixid, J Borrell, G Singh, ; Diksha, Mohit, P Acharya, D Jethava, M Vasava, Z Bhavsar, M Bhoi, D Rajani, H Patel, S Jindal, K Meena   +99 more
openalex   +1 more source

Coupling of transcription and replication machineries in the λ DNA replication initiation: evidence for direct interaction of Escherichia coli RNA polymerase and the lambda O protein [PDF]

, 2011
Transcription proceeding downstream of the lambda phage replication origin was previously shown to support initial steps of the lambda primosome assembly in vitro and to regulate frequency and directionality of lambda DNA replication in vivo.
Glinkowska, Monika, Pierechod, Marcin, Szambowska, Anna, Węgrzyn, Grzegorz   +3 more
core  

Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification [PDF]

, 2016
Filamentation induced by cyclic AMP (FIC)-domain enzymes catalyze adenylylation or other posttranslational modifications of target proteins to control their function.
Aragão, Hugo, Burmann, Björn M., Dehio, Christoph, Harms, Alexander, Hiller, Sebastian, Mazur, Adam, Schirmer, Tilman, Sharpe, Timothy, Stanger, Frédéric V.   +8 more
core   +1 more source

Antimicrobial Activity of 2-(Piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione against Staphylococcus Strains

Molecules
There is an urgent need to discover and develop novel antibacterial agents. Accordingly, we synthesised 2-(piperazin-1-yl)naphtho[2,3-d]thiazole-4,9-dione (PNT), which exhibits antimicrobial activity.
Tamami Haraguchi, Saki Hayashi, Seira Nakasaka, Yoshiro Hatanaka, Toshihiro Nagao, Shigemitsu Tanaka, Miki Yoshii, Fumiko Hara, Masayori Hagimori, Miyako Yoshida   +9 more
doaj   +1 more source