Results 121 to 130 of about 19,626 (172)

Two classes of DNA gyrase inhibitors elicit distinct evolutionary trajectories toward resistance in gram-negative pathogens. [PDF]

NPJ Antimicrob Resist
Leyn SA, Kent JE, Zlamal JE, Elane ML, Vercruysse M, Osterman AL.   +5 more
europepmc   +1 more source

Dynamic Profiling and Binding Affinity Prediction of NBTI Antibacterials against DNA Gyrase Enzyme by Multidimensional Machine Learning and Molecular Dynamics Simulations. [PDF]

ACS Omega
Kokot M, Minovski N.
europepmc   +1 more source

Multimodal antibacterial potency of newly designed and synthesized Schiff's/Mannich based coumarin derivatives: potential inhibitors of bacterial DNA gyrase and biofilm production. [PDF]

RSC Adv
Pakeeraiah K, Swain PP, Sahoo A, Panda PK, Mahapatra M, Mal S, Sahoo RK, Sahu PK, Paidesetty SK.   +8 more
europepmc   +1 more source

New quinazolin-2,4-dione derivatives incorporating acylthiourea, pyrazole and/or oxazole moieties as antibacterial agents via DNA gyrase inhibition. [PDF]

RSC Adv
Ibrahim AOA, Hassan A, Mosallam AM, Khodairy A, Rashdan HRM, Abdelmonsef AH.   +5 more
europepmc   +1 more source

Structure of Escherichia coli DNA gyrase with chirally wrapped DNA supports ratchet-and-pawl mechanism for an ATP-powered supercoiling motor

Michalczyk E, Pabiś M, Heddle J, Ghilarov D.   +3 more
europepmc   +1 more source

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DNA Gyrase: Structure and Function

Critical Reviews in Biochemistry and Molecular Biology, 1991
DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA.
Anthony Maxwell
exaly   +3 more sources

Inhibitors of DNA gyrase

Pharmacology & Therapeutics, 1989
Since the action of the two major classes of gyrase inhibitor, the coumarins and the quinolones, differ mechanistically, their primary physiological effects are described separately. These discussions include aspects of inhibition of eukaryotic topoisomerases to facilitate a comparison of prokaryotic and eukaryotic organisms. We then address the repair
K, Drlica, S, Coughlin
openaire   +2 more sources

A Comprehensive Review on DNA Gyrase Inhibitors

Infectious Disorders - Drug Targets, 2021
The newly emerging infectious organisms, the global crisis in antibiotic resistance, and the threat of bioterrorism create an urgent need to discover novel antimicrobial agents. In order to develop novel antimicrobial agents, the mechanism of infectious disease must be better understood.
S.R. Chitra, N. Ramalakshmi, Subramani Arunkumar, P. Manimegalai   +3 more
openaire   +2 more sources

DNA supercoiling by DNA gyrase

Cell Biophysics, 1988
Using purified DNA gyrase to supercoil circular plasmid pBR322 DNA, we examined how the linking number attained at the steady state ('static head') varies with the concentrations of ATP and ADP, both in the absence and presence of spermidine. In the absence of spermidine at total adenine nucleotide concentrations between 0.35 and 1.4 mM, the static ...
H V, Westerhoff, M H, O'Dea, A, Maxwell, M, Gellert   +3 more
openaire   +2 more sources

DNA Gyrase and the Supercoiling of DNA

Science, 1980
Negative supercoiling of bacterial DNA by DNA gyrase influences all metabolic processes involving DNA and is essential for replication. Gyrase supercoils DNA by a mechanism called sign inversion, whereby a positive supercoil is directly inverted to a negative one by passing a DNA segment through a transient double-strand break.
openaire   +2 more sources