Escherichia coli gyrase holocomplex with 217 bp phage Mu SGS DNA and Albi-2 stabilised by ADPNP
, 2022 Elizabeth Michalczyk, Dmitry Ghilarov
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Journal of BacteriologyDNA gyrase is an essential bacterial-specific type IIA topoisomerase that corrects DNA overwinding during transcription and replication. Compounds capable of stabilizing gyrase-mediated double-strand DNA breaks are valuable antibacterials; however, these
Chih-Han Tu +3 more
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The Effect of Compositional Context on Synthetic Gene Networks [PDF]
, 2016 It is well known that synthetic gene expression is highly sensitive to how genetic elements (promoter structure, spacing regions between promoter and coding sequences, ribosome binding sites, etc.) are spatially configured.
Beck, James L. +7 more
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Identification of novel bacterial DNA gyrase inhibitors: An in silico study
Research in Pharmaceutical Sciences, 2016 Owing to essential role in bacterial survival, DNA gyrase has been exploited as a validated drug target. However, rapidly emerging resistance to gyrase-targeted drugs such as widely utilized fluoroquinolones reveals the necessity to develop novel ...
Hamzeh Rahimi +4 more
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The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus [PDF]
, 2013 BACKGROUND: The increase in antibiotic resistant bacteria has led to renewed interest in development of alternative antimicrobial compounds such as antimicrobial peptides (AMPs), either naturally-occurring or synthetically-derived.
Cohn, Marianne T +9 more
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The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase. [PDF]
, 1991 J. L. Vizán +3 more
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DNA gyrase stimulates transcription.
Nucleic acids research, 1981 The nuclear DNA of HeLa cells can now be isolated unbroken and supercoiled. Using DNA gyrase and the untwisting enzyme, we have prepared an allomorphic series of templates derived from this nuclear DNA, and also from the circular DNA of the bacterial virus, PM2. We have then transcribed these templates using 2 different RNA polymerases--from wheat germ
Akrigg, A, Cook, P
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Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]
, 2015 Alexander Harms +8 more
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Compounding Effects of Climate Warming and Antibiotic Resistance. [PDF]
, 2020 Bacteria have evolved diverse mechanisms to survive environments with antibiotics. Temperature is both a key factor that affects the survival of bacteria in the presence of antibiotics and an environmental trait that is drastically increasing due to ...
Cruz-Loya, Mauricio +4 more
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Molecular Cloning of the gyrA and gyrB Genes of Bacteroides fragilis Encoding DNA Gyrase [PDF]
, 1999 Yoshikuni Onodera, Kenichi Sato
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