Results 11 to 20 of about 38,912 (254)

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens

Antibiotics, 2022
DNA gyrase and topoisomerase IV are proven to be validated targets in the design of novel antibacterial drugs. In this study, we report the antibacterial evaluation and molecular docking studies of previously synthesized two series of cyclic ...
Neveen M. Saleh, Yasmine S. Moemen, Sara H. Mohamed, Ghady Fathy, Abdullah A. S. Ahmed, Ahmed A. Al-Ghamdi, Sami Ullah, Ibrahim El-Tantawy El Sayed   +7 more
doaj   +1 more source

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase. [PDF]

PLoS ONE, 2017
To combat the threat of antibiotic-resistant Gram-negative bacteria, novel agents that circumvent established resistance mechanisms are urgently needed.
Scott S Walker, Marc Labroli, Ronald E Painter, Judyann Wiltsie, Brad Sherborne, Nicholas Murgolo, Xinwei Sher, Paul Mann, Paul Zuck, Charles G Garlisi, Jing Su, Stacia Kargman, Li Xiao, Giovanna Scapin, Scott Salowe, Kristine Devito, Payal Sheth, Nichole Buist, Christopher M Tan, Todd A Black, Terry Roemer   +20 more
doaj   +1 more source

Synthesis, structure and antibacterial activity of potent DNA gyrase inhibitors: N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide derivatives. [PDF]

PLoS ONE, 2013
A total of 19 novel (3a-3s) N'-benzoyl-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide analogs were designed, synthesized, and evaluated for biological activities as potential DNA gyrase inhibitors. The results showed that compound 3k can strongly inhibit
Juan Sun, Peng-Cheng Lv, Yong Yin, Rong-Ju Yuan, Jian Ma, Hai-Liang Zhu   +5 more
doaj   +1 more source

Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India. [PDF]

PLoS ONE, 2015
Enteric fever is a major cause of morbidity in several parts of the Indian subcontinent. The treatment for typhoid fever majorly includes the fluoroquinolone group of antibiotics.
Manoj Kumar, Sushila Dahiya, Priyanka Sharma, Sujata Sharma, Tej P Singh, Arti Kapil, Punit Kaur   +6 more
doaj   +1 more source

Helical Chirality: a Link between Local Interactions and Global Topology in DNA [PDF]

, 2010
DNA supercoiling plays a major role in many cellular functions. The global DNA conformation is however intimately linked to local DNA-DNA interactions influencing both the physical properties and the biological functions of the supercoiled molecule ...
A Minsky, A Stasiak, A Travers, AA Kornyshev, AA Travers, AA Vetcher, AK McClendon, AV Vologodskii, AV Vologodskii, BF Eichman, C Brochier-Armanet, CJ Benham, DE Pulleyblank, DI Cherny, DM Lilley, E Marguet, EL Zechiedrich, F Charbonnier, FH Crick, G Charvin, H Wong, HM Berman, IG Panyutin, J Yan, JC Wang, JF Marko, KC Dong, KC Neuman, KD Corbett, KD Corbett, L Postow, LF Liu, LS Shlyakhtenko, LS Shlyakhtenko, M Graille, M Kampmann, MD Stone, N Nöllmann, NJ Crisona, O Espeli, O Guipaud, P Forterre, P Forterre, P Lopez-Garcia, P Lopez-Garcia, P Várnai, PJJ Robinson, Péter Várnai, R Kanaar, R Lavery, S Inoue, S Shaw, S Trigueros, SS Zakharova, Stefan Wölfl, T Bankhead, T Schalch, T Schlick, T Stuchinskaya, TR Strick, V Katrich, V Stupina, VV Rybenkov, W Humphrey, WK Olson, WL DeLano, X Qiu, Y Timsit, Y Timsit, Y Timsit, Y Timsit, Y Timsit, Y Timsit, Y-C Xu, Youri Timsit, Z Liu, ZJ Tan   +76 more
core   +10 more sources

The bacteriophage LUZ24 “Igy” peptide inhibits the Pseudomonas DNA gyrase

Cell Reports, 2021
Summary: The bacterial DNA gyrase complex (GyrA/GyrB) plays a crucial role during DNA replication and serves as a target for multiple antibiotics, including the fluoroquinolones.
Jeroen De Smet, Jeroen Wagemans, Maarten Boon, Pieter-Jan Ceyssens, Marleen Voet, Jean-Paul Noben, Julia Andreeva, Dmitry Ghilarov, Konstantin Severinov, Rob Lavigne   +9 more
doaj   +1 more source

CID12261165, a flavonoid compound as antibacterial agents against quinolone-resistant Staphylococcus aureus

Scientific Reports, 2023
Flavonoids are plant-produced secondary metabolites that are found ubiquitously. We have previously reported that apigenin, a class of flavonoid, has unique antimicrobial activity against Staphylococcus aureus (S.
Yuh Morimoto, Yoshifumi Aiba, Kazuhiko Miyanaga, Tomomi Hishinuma, Longzhu Cui, Tadashi Baba, Keiichi Hiramatsu   +6 more
doaj   +1 more source

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

Nature Communications, 2021
The mechanism of DNA gyrase inhibitor stabilization of single-strand DNA cleavage breaks by DNA gyrase has been hypothetical. Here, the authors show experimental evidence of the mechanism using a library of inhibitors with improved binding and employ ...
Anja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh   +9 more
doaj   +1 more source

Bacterial Argonaute Proteins Aid Cell Division in the Presence of Topoisomerase Inhibitors in Escherichia coli

Microbiology Spectrum, 2023
Prokaryotic Argonaute (pAgo) proteins are guide-dependent nucleases that function in host defense against invaders. Recently, it was shown that TtAgo from Thermus thermophilus also participates in the completion of DNA replication by decatenating ...
Anna Olina, Aleksei Agapov, Denis Yudin, Dmitry Sutormin, Alina Galivondzhyan, Anton Kuzmenko, Konstantin Severinov, Alexei A. Aravin, Andrey Kulbachinskiy   +8 more
doaj   +1 more source

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source