Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]
, 2015 We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth +12 more
core +2 more sources
A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance [PDF]
, 2018 Imidazopyrazinones (IPYs) are a new class of compounds that target bacterial topoisomerases as a basis for their antibacterial activity. We have characterized the mechanism of these compounds through structural/mechanistic studies showing they bind and ...
Bacqué, Eric +7 more
core +2 more sources
Frontiers in Cellular and Infection Microbiology, 2019 Drug tolerance in mycobacterial pathogens is a global concern. Fluoroquinolone (FQ) treatment is widely used for induction of persisters in bacteria.
Eira Choudhary +4 more
doaj +1 more source
In silico analysis of ciprofloxacin analogs as inhibitors of DNA gyrase of Staphylococcus aureus
Informatics in Medicine Unlocked, 2021 In this in silico study, thirty-five ciprofloxacin analogs were docked to the active site of DNA gyrase, the prime target of ciprofloxacin type antibiotics. Prior to docking all the structures were optimized using MM2 force field parameters.
Md. Rakhibul Hasan +7 more
doaj +1 more source
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.
PLoS Genetics, 2020 DNA supercoiling is essential for all living cells because it controls all processes involving DNA. In bacteria, global DNA supercoiling results from the opposing activities of topoisomerase I, which relaxes DNA, and DNA gyrase, which compacts DNA. These
Alexandre Duprey, Eduardo A Groisman
doaj +1 more source
Microbiology Spectrum, 2022 The aminobenzimidazole SPR719 targets DNA gyrase in Mycobacterium tuberculosis. The molecule acts as inhibitor of the enzyme’s ATPase located on the Gyrase B subunit of the tetrameric Gyrase A2B2 protein.
Wassihun Wedajo Aragaw +6 more
doaj +1 more source
Tissue-specific Salmonella Typhimurium gene expression during persistence in pigs [PDF]
, 2011 Salmonellosis caused by Salmonella Typhimurium is one of the most important bacterial zoonotic diseases. The bacterium persists in pigs resulting in asymptomatic 'carrier pigs', generating a major source for Salmonella contamination of pork.
Boyen, Filip +5 more
core +2 more sources
“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]
, 2014 The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova +110 more
core +1 more source
Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.
PLoS ONE, 2010 BackgroundDNA topoisomerases are enzymes that control the topology of DNA in all cells. DNA gyrase is unique among the topoisomerases in that it is the only enzyme that can actively supercoil DNA using the free energy of ATP hydrolysis.
Katherine M Evans-Roberts +4 more
doaj +1 more source
A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]
, 2014 Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A +6 more
core +2 more sources