Results 11 to 20 of about 2,395,071 (348)
The CMG DNA helicase and the core replisome.
Current Opinion in Structural Biology, 2023 Eukaryotic DNA replication is performed by the replisome, a large and dynamic multi-protein machine endowed with the required enzymatic components for the synthesis of new DNA. Recent cryo-electron microscopy (cryoEM) analyses have revealed the conserved
L. Pellegrini
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Deinococcus radiodurans PriA is a Pseudohelicase. [PDF]
PLoS ONE, 2015 Reactivation of repaired DNA replication forks in bacteria is catalyzed by PriA helicase. This broadly-conserved bacterial enzyme can remodel the structure of DNA at a repaired DNA replication fork by unwinding small portions of duplex DNA to prepare the
Matthew E Lopper +2 more
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Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile [PDF]
Open Biology, 2016 DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA ...
Erika van Eijk +8 more
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Microbiology Spectrum, 2023 DNA replication is a standard and essential function among DNA viruses; however, this functional domain's common ancestor, origin, and evolutionary path in invertebrate- and vertebrate-infecting viruses are not yet fully understood.
Perumal Arumugam Desingu +2 more
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Eukaryotic DNA helicases [PDF]
FEBS Letters, 1990 DNA is very stable in its double‐stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single‐stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nucleoside‐5'‐triphosphate hydrolysis.
Thömmes P, Hübscher U
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Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD. [PDF]
PLoS ONE, 2013 DNA helicases are responsible for unwinding the duplex DNA, a key step in many biological processes. UvrD is a DNA helicase involved in several DNA repair pathways.
Meike Stelter +3 more
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The RecQ DNA Helicases in DNA Repair [PDF]
Annual Review of Genetics, 2010 The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop)
Bernstein, Kara +2 more
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Unwinding of Nucleosomal DNA by a DNA Helicase [PDF]
Journal of Biological Chemistry, 1995 We have asked whether a DNA helicase can unwind DNA contained within both isolated native chromatin and reconstituted chromatin containing regularly spaced arrays of nucleosome cores on a linear tandem repeat sequence. We find that Escherichia coli recBCD enzyme is capable of unwinding these DNA substrates and displacing the nucleosomes, although both ...
A K, Eggleston +3 more
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Mutations altering the interplay between GkDnaC helicase and DNA reveal an insight into helicase unwinding. [PDF]
PLoS ONE, 2011 Replicative helicases are essential molecular machines that utilize energy derived from NTP hydrolysis to move along nucleic acids and to unwind double-stranded DNA (dsDNA).
Yu-Hua Lo +4 more
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Life Science Alliance, 2021 WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors. Loss of WRN, a DNA repair helicase, was
Joseph A Newman +12 more
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