Results 261 to 270 of about 1,562,024 (293)
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DNA Helicases of Escherichia coli
1991A great deal has been learned in the last 15 years with regard to how helicase enzymes participate in DNA metabolism and how they interact with their DNA substrates. However, many questions remain unanswered. Of critical importance is an understanding of how NTP hydrolysis and hydrogen-bond disruption are coupled.
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Helicases, G4‐DNAs, and Drug Design
ChemMedChem, 2014AbstractNew helicase assays that recognise therapeutically important G4‐DNA structures will lead to the discovery of novel molecular entities that bind not only to G4‐tetrads, but also to grooves and loops of G4‐DNA. Such assays can also provide inhibitors of G4‐specific helicases that will shed light on the emerging involvement of helicases in cancer ...
Tracy K, Hale +3 more
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Molecular Characterization of Nuclear DNA Helicase II (RNA Helicase A)
2009Nuclear DNA helicase II (NDH II) was first isolated from calf thymus using a DNA-unwinding assay. Subsequently it has been shown to be a homologue of human RNA helicase A (RHA) and the maleless protein (MLE) from Drosophila. Accordingly, the protein possesses both DNA and RNA unwinding activities.
Suisheng, Zhang, Frank, Grosse
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Evidence for a Role of DNA Helicase II in DNA Replication
1981Studies using antibodies raised against DNA helicase II of E.coli and applied to subcellular E.coli DNA replicating systems suggest that DNA helicase II participates in the unwinding of DNA molecules, which initiate replication as closed circles. A similar role for the rep protein has been implicated in the rolling circle model of replication of the ...
Klinkert, M., Abdel-Monem, M.
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DNA helicases in recombination
2007The different pathways of homologous recombination involve the recognition and pairing of homologous DNA sequences promoted by proteins that catalyze strand exchange. Other steps in recombination involve double stranded DNA unwinding for branch migration activities, and in some cases the reannealing of single DNA strands.
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Biochemical Assays for the Characterization of DNA Helicases
2008Helicases are ubiquitous enzymes that disrupt complementary strands of duplex nucleic acid in a reaction dependent on nucleoside-5'-triphosphate hydrolysis. Helicases are implicated in the metabolism of DNA structures that are generated during replication, recombination, and DNA repair. Furthermore, an increasing number of helicases have been linked to
Robert M, Brosh, Sudha, Sharma
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DNA Helicases and DNA Motor Proteins
2012Preface.- Overview: What are DNA helicases?.- Structure and mechanisms of SF1 DNA helicases.- Structure and mechanisms of SF2 DNA helicases.- Structure and mechanisms of hexameric helicases.- Helicases at the replication fork.- DNA helicases associated with genetic instability, cancer and aging.- The Helicase-primase complex as a target for effective ...
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RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells
DNA Repair, 2021Edus H Warren, Michael Cargill
exaly