Results 221 to 230 of about 533,967 (266)
Some of the next articles are maybe not open access.
Retroviral DNA integration: Structure of an integration intermediate
Cell, 1988The structure of a presumptive DNA intermediate in the integration of retroviral DNA was studied in a cell-free reaction with exogenously added target DNA. The product made by viral core particles of Moloney murine leukemia virus (Mo-MLV) containing linear viral DNA has a structure consistent with an integration mechanism similar to that observed ...
T, Fujiwara, K, Mizuuchi
openaire +2 more sources
Teratogenesis, Carcinogenesis, and Mutagenesis, 1997
Since the 1970s there have been conflicting reports of decreasing sperm counts in man and increasing testicular cancer. There is a hypothetical link between apparent adverse trends in several measures of human reproductive health and exposure to endocrine disrupters.
D, Anderson +5 more
openaire +2 more sources
Since the 1970s there have been conflicting reports of decreasing sperm counts in man and increasing testicular cancer. There is a hypothetical link between apparent adverse trends in several measures of human reproductive health and exposure to endocrine disrupters.
D, Anderson +5 more
openaire +2 more sources
Microfluidic-integrated DNA nanobiosensors
Biosensors and Bioelectronics, 2016Over the last few decades, an increased demand has emerged for integrating biosensors with microfluidic- and nanofluidic-based lab-on-chip (LOC) devices for point-of-care (POC) diagnostics, in the medical industry and environmental monitoring of pathogenic threat agents. Such a merger of microfluidics with biosensing technologies allows for the precise
Ansari M.I. Haque +3 more
openaire +2 more sources
CMOS Integrated DNA Chip for Quantitative DNA Analysis
2006 IEEE International Solid State Circuits Conference - Digest of Technical Papers, 2006Quantitative gene expression analysis, based on an electrochemical DNA-detection method uses immobilized DNA probes on Au electrodes with diameters from 200mum to 2mum. Cyclic voltammetry is used to measure anodic current from the intercalators. The 25times3mm2 IC, fabricated in 1mum 2M CMOS, contains 40 electrodes, 1600 transistors and dissipates ...
Nobuhiro Gemma +4 more
openaire +1 more source
T-DNA integration: Pol θ controls T-DNA integration
Nature Plants, 2016The mechanism for T-DNA integration, a critical step of Agrobacterium-mediated transgenesis, remains poorly understood. Now, a study based on mutant analysis shows that Pol θ controls T-DNA integration and generates error-prone footprints at integration sites.
openaire +2 more sources
BioEssays, 1984
AbstractThe synthesis and integration of DNA into the genome of its host cell is a normal step in the replication of the retroviruses. Previous studies have provided details concerning the structure of viral DNA and viral and host integration sites. More recent genetic and biochemical results have expanded our understanding considerably: it should soon
Anna Marie Skalka, Jonathan Leis
openaire +1 more source
AbstractThe synthesis and integration of DNA into the genome of its host cell is a normal step in the replication of the retroviruses. Previous studies have provided details concerning the structure of viral DNA and viral and host integration sites. More recent genetic and biochemical results have expanded our understanding considerably: it should soon
Anna Marie Skalka, Jonathan Leis
openaire +1 more source
1990
Integration of a DNA copy of the viral genome into host cellular DNA is an essential step in the life cycle of most, if not all, retroviruses (Donehower and Varmus 1984; Schwartzberg et al. 1984a; Panganiban and Temin 1984b; Colicelli and Goff 1985; Harris et al. 1984). Since retroviral DNA molecules are not ordinarily able to replicate autonomously as
openaire +2 more sources
Integration of a DNA copy of the viral genome into host cellular DNA is an essential step in the life cycle of most, if not all, retroviruses (Donehower and Varmus 1984; Schwartzberg et al. 1984a; Panganiban and Temin 1984b; Colicelli and Goff 1985; Harris et al. 1984). Since retroviral DNA molecules are not ordinarily able to replicate autonomously as
openaire +2 more sources
2017
Homeostasis comprises the tendency of an organism or cell to regulate their chemical processes that take place internally so as to maintain health, vital functions and stability, owing to the coordinated response of its parts to any situation or stimulus tending to disturb its normal condition or function. But how do cells work in order to preserve DNA
Segatto, Marcela +1 more
openaire +2 more sources
Homeostasis comprises the tendency of an organism or cell to regulate their chemical processes that take place internally so as to maintain health, vital functions and stability, owing to the coordinated response of its parts to any situation or stimulus tending to disturb its normal condition or function. But how do cells work in order to preserve DNA
Segatto, Marcela +1 more
openaire +2 more sources
Nuclear integrations of mitochondrial DNA in gorillas
American Journal of Primatology, 2004AbstractGreat ape systematics, particularly at the species level and below, is currently under debate, due in part to the recent influx of molecular data. The phylogenies of previously published mitochondrial control region (or D‐loop) DNA sequences in gorillas show deep splits within West African gorillas (Gorilla gorilla gorilla), and very high ...
Michael I, Jensen-Seaman +3 more
openaire +2 more sources
An Integrated Workflow for DNA Methylation Analysis
Journal of Genetics and Genomics, 2013The analysis of cytosine methylation provides a new way to assess and describe epigenetic regulation at a whole-genome level in many eukaryotes. DNA methylation has a demonstrated role in the genome stability and protection, regulation of gene expression and many other aspects of genome function and maintenance.
Pingchuan, Li +5 more
openaire +2 more sources