Results 171 to 180 of about 337,826 (349)

Specific Interaction of DNA Polymerase β and DNA Ligase I in a Multiprotein Base Excision Repair Complex from Bovine Testis [PDF]

, 1996
Rajendra Prasad, Rakesh Kumar Singhal, Deepak Srivastava, J. Thomas Molina, Alan E. Tomkinson, Samuel H. Wilson   +5 more
openalex   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma

Translational Oncology
Segmental chromosomal alterations, including 11q deletion and 17q gain, are the strongest predictors of pediatric neuroblastoma relapse. These alterations result from unbalanced translocations linked to erroneous DNA repair.
Sahiti Chukkapalli, Keyonna Williams, Biao Hu, Kimber Converso-Baran, Olivia Tussing, Patrick O'Brien, Nouri Neamati, Erika A. Newman   +7 more
doaj  

A Commentary on Mitochondrial Dysfunction and Compromised DNA Repair in Neurodegeneration: The Emerging Role of FUS in ALS

Neuroscience Insights
Mitochondrial dysfunction plays a pivotal role in the progression of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, and Parkinson’s disease.
Manohar Kodavati, Muralidhar L Hegde
doaj   +1 more source

DNA Ligase 4 Contributes to Cell Proliferation against DNA-PK Inhibition in MYCN-Amplified Neuroblastoma IMR32 Cells. [PDF]

Int J Mol Sci, 2023
Ando K, Suenaga Y, Kamijo T.
europepmc   +1 more source

Changes of DNA Ligase in Developing Rat Brain<xref ref-type="fn" rid="fn1">¹</xref>

, 1977
Noriko Nakaya, Yoshioi Sawasaki, Hirobumi Teraoka, Hiroshi Nakajima, Kinji Tsukada   +4 more
openalex   +1 more source

Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression

Advanced Science, EarlyView.
GLed, a reversible lanthanide‐based GSH sensor that enables real‐time, single‐cell measurement of Gamma–Glutamyl Cysteine Ligase (GCL) activity ‐whose role in human T cells remains unclear‐ is developed. GLed directly links GCL activity to T cell effector functions and reveals its modulation by immunosuppressive drugs, identifying GCL as a critical ...
Francisco Fueyo‐González, Carmen Salto‐Giron, Mehek Ningoo, Laura Espinar‐Barranco, Rafael Salto, Jose Manuel Paredes, Rosario Herranz, Angel Orte, Miguel Fribourg, Juan A. González‐Vera   +9 more
wiley   +1 more source

Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin. [PDF]

J Transl Med, 2022
Caracciolo D, Juli G, Riillo C, Coricello A, Vasile F, Pollastri S, Rocca R, Scionti F, Polerà N, Grillone K, Arbitrio M, Staropoli N, Caparello B, Britti D, Loprete G, Costa G, Di Martino MT, Alcaro S, Tagliaferri P, Tassone P.   +19 more
europepmc   +1 more source

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro [PDF]

, 1996
Keith W. Caldecott, Saïd Aoufouchi, Peter Johnson, Sidney SHALL   +3 more
openalex   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source