Results 171 to 180 of about 208,982 (285)

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

Crystal structure of ATP-dependent DNA ligase from Rhizobium phage vB_RleM_P10VF. [PDF]

Acta Crystallogr F Struct Biol Commun
Rothweiler U, Leiros HKS, Williamson A.
europepmc   +1 more source

Cognate base-pair selectivity of hydrophobic unnatural bases in DNA ligation by T4 DNA ligase. [PDF]

Biopolymers, 2021
Kimoto M, Soh SHG, Tan HP, Okamoto I, Hirao I.   +4 more
europepmc   +1 more source

Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications [PDF]

, 2000
Jae Young Lee, Changsoo Chang, Hyun Kyu Song, Jinho Moon, Jin Kuk Yang, Hyun-Kyu Kim, Suk-Tae Kwon, Se Won Suh   +7 more
openalex   +1 more source

An LCN2‐Dependent Positive‐Feedback Loop Between Gastric Cancer Cells and Tumor‐Associated‐Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis

Advanced Science, EarlyView.
In this study, the expression and function of LCN2 in GC is aimed to investigate and elucidate the mechanisms by which the LCN2‐dependent positive‐feedback loop between GC cells and TAMs drives lymphangiogenesis and lymphatic metastasis. These findings suggest that LCN2 may serve as a potential prognostic biomarker and therapeutic target in GC ...
Zhixin Huang, Ying Li, Yan Qian, Linying Ye, Tianhao Zhang, Yang Cheng, Jialin Wu, Peng Duan, Tiantian Zhang, Zihan Yu, Zeyu Zhao, Risheng Zhao, Zhi Liang, Ertao Zhai, Shirong Cai, Jianhui Chen   +15 more
wiley   +1 more source

Molecular basis for RNA discrimination by human DNA ligase 1. [PDF]

Nucleic Acids Res
Tumbale PP, Jurkiw TJ, Krahn JM, Bokil NV, Admiraal SJ, Pedersen LC, Williams JS, Kunkel TA, O'Brien PJ, Williams RS.   +9 more
europepmc   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Influence of the ATP-dependent DNA ligase, Lig E, on <i>Neisseria gonorrhoeae</i> microcolony and biofilm formation. [PDF]

Biofilm
Pan J, Albarrak A, Hicks J, Williams D, Williamson A.   +4 more
europepmc   +1 more source

Post-replicative nick translation occurs on the lagging strand during prolonged depletion of DNA ligase I in Saccharomyces cerevisiae. [PDF]

G3 (Bethesda), 2021
Koussa NC, Smith DJ.
europepmc   +1 more source

An etoposide-induced block in vaccinia virus telomere resolution is dependent on the virus-encoded DNA ligase

, 1995
A M DeLange, Michael Carpenter, Judy Choy, V E Newsway   +3 more
openalex   +1 more source