Results 231 to 240 of about 113,019 (248)

ATP‐ and NAD⁺‐dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii [PDF]

Molecular Microbiology, 2005
SummaryDNA ligases join the ends of DNA molecules during replication, repair and recombination. ATP‐dependent ligases are found predominantly in the eukarya and archaea whereas NAD+‐dependent DNA ligases are found only in the eubacteria and in entomopoxviruses.
An Zhao, Fiona C. Gray, Stuart A. MacNeill   +2 more
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Interaction of beta-L-adenosine-5'-triphosphate (L-ATP) with human deoxycytidine kinase, human DNA primase and T4 DNA ligase: does the chance direct enzymatic enantioselectivity?

Nucleosides and Nucleotides, 1999
We demonstrate that L-ATP: 1) as well as its natural D-enantiomer, acts as a phosphate donor in the reaction catalysed by human deoxycytidine kinase; 2) inhibits human DNA-primase and the ATP-dependent T4 DNA ligase. Thus, the lack of enantioselectivity of the enzymes is more frequent than it was believed a few years ago and we suggest that it would ...
A. Verri, A. Montecucco, G. Gosselin, V. Boudou, S. Spadari, J. Imbach, F. Focher   +6 more
semanticscholar   +5 more sources

Structure and activity of a minimal-type ATP-dependent DNA ligase from a psychrotolerant bacterium

, 2014
Adele Williamson, Ulli Rothweiler, Hanna‐Kirsti S. Leiros   +2 more
openalex   +2 more sources

DNA Ligase From Thermococcus radiotolerans: Recombinant Production, Characterization, Up‐Scale Fermentation, and In Silico Evaluation

Biotechnology and applied biochemistry
The present study describes molecular cloning, Escherichia coli expression, purification, and characterization of a DNA ligase from Thermococcus radiotolerans (TR). Optimal pH, temperature, media composition, and inducer concentrations for the production
Ahmed Osman, S. Iftikhar, B. N. Murtaza, S. Hosawi, Hisham N Tayeb, Thamir M. Eid, Hayam A Alwabsi, Muhammad Shahid Nadeem   +7 more
semanticscholar   +1 more source

ATP dependent DNA ligase from S. solfataricus bound to ATP

, 2006
John M. Pascal, Tom Ellenberger
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Functional domains of an ATP-dependent DNA ligase.

Journal of molecular biology, 1999
The crystal structure of an ATP-dependent DNA ligase from bacteriophage T7 revealed that the protein comprised two structural domains. In order to investigate the biochemical activities of these domains, we have overexpressed them separately and purified them to homogeneity. The larger N-terminal domain retains adenylation and ligase activities, though
A J, Doherty, D B, Wigley
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Synthesis and bioevaluation of aryl hydroxamates distinguishing between NAD+ and ATP-dependent DNA ligases

MedChemComm, 2012
Identification of compounds distinguishing between NAD+ and ATP-dependent ligases is a key factor to discover new antimicrobials. Based on virtual screening experiments a series of hydroxamates distinguishing between the above two classes of enzymes are synthesized.
Vandna Kukshal, Mridul Mishra, Arya Ajay, Taran Khanam, Rahul Sharma, Divya Dube, Deepti Chopra, Rama Pati Tripathi, Ravishankar Ramachandran   +8 more
openaire   +1 more source

A new group of plant-specific ATP-dependent DNA ligases identified by protein phylogeny, hydrophobic cluster analysis and 3-dimensional modelling

Functional Plant Biology, 2005
The eukaryotic ATP-dependent DNA ligases comprise a group of orthologous proteins that have distinct roles in DNA metabolism. In contrast with the well-known DNA ligases of animal cells, the DNA ligases of plant cells are poorly described. Until now, only two DNA ligases (I and IV) genes of Arabidopsis thaliana (L.) Heynh were isolated and ...
Diego, Bonatto, Martin, Brendel, João Antonio Pêgas, Henriques   +2 more
openaire   +2 more sources

[Inhibitory effect of ATP gamma-anilide in reactions catalyzed by amino acid:tRNA ligases and DNA-dependent RNA polymerase].

Doklady Akademii nauk SSSR, 1974
Babkina Gt, Knorre Vl, Knorre Dg, Lavrik Oi   +3 more
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mycobacterial DNA ligase D complexed with ATP and Mg

, 2019
S. Shuman, M. Unciuleac, Y. Goldgur
semanticscholar   +1 more source