Results 231 to 240 of about 145,020 (273)

Three‐Segment Protein Labeling Using a Highly Efficient and Cysteine‐Less Split Intein Identified with Computational Prediction of Aggregation Properties

Angewandte Chemie, EarlyView.
Tandem protein trans‐splicing (PTS) assembles a protein from three segments. Expanding this technology to individually treat cysteines in each segment, for example, for chemical labeling using thiol bioconjugation, the authors identify a second, highly efficient cysteine‐less split intein.
Christoph Humberg, Jonas Kröger, Shmuel Pietrokovski, Henning D. Mootz   +3 more
wiley   +2 more sources

Whole genome sequence of the syntrophic benzoate-degrading bacterium, <i>Syntrophus buswellii</i> DSM 102354^<b>T</b>. [PDF]

Microbiol Resour Announc
Gunsalus RP, Humm E, Cook L, Wofford NQ, James KL, Pellegrini M, Morselli M, Ha SM, McInerney MJ.   +8 more
europepmc   +1 more source

Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi

Angewandte Chemie, EarlyView.
Type III polyketide synthases (T3PKSs) produce diverse compounds of ecological and clinical importance. Here, the activity of 37 fungal T3PKSs was profiled, revealing unexpected products and generating several pharmaceutical precursors. The machine learning model trained on the activity data accurately extrapolates the predictions to other enzymes and ...
Nika Sokolova, Stepan S. Denisov, Thomas Hackl, Kristina Haslinger   +3 more
wiley   +1 more source

ATP‐Powered Signaling Between Artificial and Living Cells

Angewandte Chemie, EarlyView.
We introduce an ATP‐powered artificial cell platform capable of selectively and transiently releasing DNA signals to facilitate communication between artificial and living cells. By engineering these DNA signals, we achieve precise activation of cellular functions and regulated delivery in response to ATP levels.
Soumya Sethi, Charu Sharma, Andreas Walther   +2 more
wiley   +2 more sources

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213. [PDF]

Nat Commun
Ahel J, Balci A, Faas V, Grabarczyk DB, Harmo R, Squair DR, Zhang J, Roitinger E, Lamoliatte F, Mathur S, Deszcz L, Bell LE, Lehner A, Williams TL, Sowar H, Meinhart A, Wood NT, Clausen T, Virdee S, Fletcher AJ.   +19 more
europepmc   +1 more source

Identifizierung eines Moleküls, das den Abbau der aktivierten Checkpoint‐Kinase‐1 auslöst und Charakterisierung der nicht‐katalytischen Funktionen von Checkpoint‐Kinase‐1 in Tumorzellen

Angewandte Chemie, EarlyView.
In Tumorzellen führt die durch HU induzierte Verlangsamung der DNA‐Replikation zur Aktivierung von CHK1 durch Autophosphorylierung, was einen Zellzyklusarrest bewirkt und die Rekrutierung des DNA‐Reparaturproteins WRN zur Förderung der DNA‐Reparatur und des Zellüberlebens ermöglicht.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Research Progress of PROTAC-Degraded CDKs in the Treatment of Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Zhao K, Zhang J, Yang Z, Wang R, Shi Y, Ji Y, Zhang S, Liu M.   +7 more
europepmc   +1 more source

Effects of Mg²⁺ and ATP on YOYO-1 labeling of genomic DNA in single molecule experiments. [PDF]

Biochem Biophys Rep
Möller C, Winter D, Nambannor Kunnath R, Kk S, Westerlund F.   +4 more
europepmc   +1 more source

Mitochondrial Quality Control in Neurodegeneration and Cancer: A Common Denominator, Distinct Therapeutic Challenges. [PDF]

Int J Mol Sci
Dominiak A, Gawinek E, Banaszek AA, Wilkaniec A.   +3 more
europepmc   +1 more source

Using BONCAT to dissect the proteome of <i>S. aureus</i> persisters. [PDF]

mSphere
George Matlalcuatzi EDC, Bakkum T, Thomas PS, Hacker S, Florea BI, Vriesendorp B, Rozen DE, van Kasteren SI.   +7 more
europepmc   +1 more source