In Bacteria, the replicative DNA ligase is NAD‐dependent. However, some bacteria possess accessory ATP‐dependent DNA ligases (ADLs) which vary in size and domain organization. Phylogenomic analyses of bacterial ADLs reveal that types Lig B, Lig C and Lig D have descended from a common ancestor, while Lig E was transferred in a separate event, possibly from a bacteriophage. For details, see the article by Williamson et al. on pp. 274‐290 of this issue. [PDF]
Molecular Microbiology, 2016 openalex +2 more sources
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases [PDF]
Biochemical Pharmacology, 2009 Compounds of the mevalonate pathway containing a terminal di- or triphosphate (mev-PP or mev-PPP) were tested as substrates of several enzyme ligases (T4 RNA ligase, T4 DNA ligase, firefly luciferase and other ligases) for the synthesis of ATP derivatives of the mev-pppA or mev-ppppA type.
Marı́a A. Günther Sillero +5 more
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Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 2022 The increase in the frequency of drug resistance in bacterial infections has led to the research of new antibacterial agents targeting new mechanisms. Many of the functions of NAD+-dependent DNA ligase have made it a remarkable target for antibacterial ...
Özlem Kaplan +2 more
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Template-directed ligation of tethered mononucleotides by t4 DNA ligase for kinase ribozyme selection. [PDF]
PLoS ONE, 2010 BACKGROUND: In vitro selection of kinase ribozymes for small molecule metabolites, such as free nucleosides, will require partition systems that discriminate active from inactive RNA species.
David G Nickens +3 more
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PprA contributes to Deinococcus radiodurans resistance to nalidixic acid, genome maintenance after DNA damage and interacts with deinococcal topoisomerases. [PDF]
PLoS ONE, 2014 PprA is known to contribute to Deinococcus radiodurans' remarkable capacity to survive a variety of genotoxic assaults. The molecular bases for PprA's role(s) in the maintenance of the damaged D.
Swathi Kota +4 more
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Analysis of the distribution and evolution of the
Molecular Microbiology, 2015 SummaryPrior to the discovery of a minimal ATP‐dependent DNA ligase in Haemophilus influenzae, bacteria were thought to only possess a NAD‐dependent ligase, which was involved in sealing of Okazaki fragments. We now know that a diverse range of bacterial species possess up to six of these accessory bacterial ATP‐dependent DNA ligases (b‐ADLs), which ...
Adele Williamson +2 more
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Biology Direct, 2009 Background Eukaryotic Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) encode most if not all of the enzymes involved in their DNA replication. It has been inferred that genes for these enzymes were already present in the last common ancestor of the NCLDV ...
Koonin Eugene V, Yutin Natalya
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ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.
PLoS Biology, 2015 Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid ...
Marcelino Bermúdez-López +11 more
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Molecules, 2017 The DNA ligases, enzymes that seal breaks in the backbones of DNA, are essential for all organisms, however bacterial ligases essential for DNA replication use β-nicotinamide adenine dinucleotide as their co-factor, whereas those that are essential in ...
Malgorzata Korycka-Machala +6 more
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Design and Synthesis of Ag Nanocluster Molecular Beacon for Adenosine Triphosphate Detection
Journal of Analytical Methods in Chemistry, 2019 This study presents a fluorescence method for detecting adenosine triphosphate (ATP) based on a label-free Ag nanocluster molecular beacon (MB) with high sensitivity.
Xiaoshuang Li +7 more
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