Results 201 to 210 of about 77,898 (323)

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

Advanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao, Yifu Shen, Zhihui Xiao, Zhenbo Han, Xu Liu, Ao Cai, Yanan Tian, Guang Lian, Wenya Ma, Yining Liu, Rui Gong, Hanjing Li, Xiuxiu Wang, Zhongyu Ren, Naufal Zagidullin, Lei Yu, Ye Tian, Yu Liu, Zhenwei Pan, Baofeng Yang, Benzhi Cai   +20 more
wiley   +1 more source

Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids. [PDF]

Int J Mol Sci
Sun D, Gokhale V.
europepmc   +1 more source

An exonic splicing silencer in the testes-specific DNA ligase III beta exon [PDF]

, 2000
S. L. Chew
openalex   +1 more source

A Molecular Recruitment Colocalization Platform for Visualizing Multi‐Protein Interactions and Engineering Biomolecular Condensates in Living Cells

Advanced Science, EarlyView.
MRC is a live‐cell method enabling visualization of protein–protein interactions and biomolecular condensates. It supports multi‐protein colocalization, binding analysis, and programmable condensate manipulation, providing a versatile platform for studying dynamic cellular organization.
Lei Peng, Yu Hou, Yan Zhao, Jing‐Ya Tang, Liu Song, Bo Peng, Min Li, Dian‐Bing Wang, Xian‐En Zhang   +8 more
wiley   +1 more source

Mammalian DNA ligases; roles in maintaining genome integrity. [PDF]

J Mol Biol
Sallmyr A, Bhandari SK, Naila T, Tomkinson AE.   +3 more
europepmc   +1 more source

Crystal structure of NAD+-dependent DNA ligase: modular architecture and functional implications [PDF]

, 2000
Jae Young Lee, Changsoo Chang, Hyun Kyu Song, Jinho Moon, Jin Kuk Yang, Hyun-Kyu Kim, Suk-Tae Kwon, Se Won Suh   +7 more
openalex   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Crystal Structure of Eukaryotic DNA Ligase–Adenylate Illuminates the Mechanism of Nick Sensing and Strand Joining [PDF]

, 2000
Mark Odell, Verl Sriskanda, Stewart Shuman, Dimitar B. Nikolov   +3 more
openalex   +1 more source

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu, Hongchao He, Shilei Qiao, Yifan Shao, Lurong Wang, Zhengkui Zhang, Long Zhang, Fangfang Zhou   +7 more
wiley   +1 more source

Specific Inhibition of the Eubacterial DNA Ligase by Arylamino Compounds

, 1999
Giovanni Ciarrocchi, Donald G. MacPhee, Les W. Deady, Leann Tilley   +3 more
openalex   +1 more source