Results 31 to 40 of about 2,392,207 (383)
DNA methylation GrimAge strongly predicts lifespan and healthspan
Aging, 2019 It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan.
A. Lu +13 more
semanticscholar +1 more source
DNA methylation-based classification of central nervous system tumours
Nature, 2018 Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—
D. Capper +142 more
semanticscholar +1 more source
A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022 Abstract Objective Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.
Jiayi Song +11 more
wiley +1 more source
Frontiers in Physiology, 2014 DNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespread DNA methylation whereas invertebrate genomes are less methylated, predominantly within gene bodies. DNA methylation in invertebrates is associated with transcription level,
Guillaume eRiviere, Guillaume eRiviere
doaj +1 more source
DNA methylation patterns and epigenetic memory.
Genes & Development, 2002 The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional ...
A. Bird
semanticscholar +1 more source
DNA methylation and cancer [PDF]
Oncogene, 2002 There is tremendous ferment in the field of epigenetics as the relationships between chromatin structure and DNA methylation patterns become clearer. Central to this activity is the realization that the 'histone code', which involves the post-translational modification of histones and which has important ramifications for chromatin structure, may be ...
openaire +5 more sources
Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies
Neuropsychopharmacology Reports, 2019 Introduction Epigenetic information such as DNA methylation is a useful biomarker that reflects complex gene‐environmental interaction. Peripheral tissues such as blood and saliva are commonly collected as the source of genomic DNA in cohort studies ...
Yui Murata +10 more
doaj +1 more source
BioTechniques, 2015 Variations in DNA methylation have been implicated in a number of disorders. Changes in global DNA methylation levels have long been associated with various types of cancer.
Elif Aysimi Duman +3 more
doaj +1 more source
Higher order methylation features for clustering and prediction in epigenomic studies [PDF]
Bioinformatics (2016) 32 (17): i405-i412, 2016 Motivation: DNA methylation is an intensely studied epigenetic mark, yet its functional role is incompletely understood. Attempts to quantitatively associate average DNA methylation to gene expression yield poor correlations outside of the well-understood methylation-switch at CpG islands.
arxiv +1 more source
Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]
Bioinformatics 30 (2014) i408-i414, 2014 Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation. Genome-wide DNA methylation assays have become increasingly common, and recently distinct stages across differentiating cellular lineages have been ...
arxiv +1 more source