Results 31 to 40 of about 2,729,754 (384)

DNA methylation-based classification of central nervous system tumours

Nature, 2018
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—
D. Capper, David T. W. Jones, M. Sill, V. Hovestadt, D. Schrimpf, D. Sturm, C. Koelsche, F. Sahm, L. Chavez, D. Reuss, A. Kratz, A. Wefers, Kristin Huang, K. Pajtler, L. Schweizer, D. Stichel, A. Olar, Nils W. Engel, K. Lindenberg, P. Harter, Anne K. Braczynski, K. Plate, H. Dohmen, B. Garvalov, R. Coras, A. Hölsken, E. Hewer, M. Bewerunge-Hudler, M. Schick, R. Fischer, R. Beschorner, J. Schittenhelm, O. Staszewski, K. Wani, P. Varlet, M. Pages, P. Temming, D. Lohmann, F. Selt, H. Witt, T. Milde, O. Witt, E. Aronica, F. Giangaspero, E. Rushing, W. Scheurlen, C. Geisenberger, F. Rodriguez, A. Becker, M. Preusser, C. Haberler, R. Bjerkvig, J. Cryan, M. Farrell, M. Deckert, J. Hench, S. Frank, J. Serrano, Kasthuri Kannan, A. Tsirigos, W. Brück, S. Hofer, S. Brehmer, M. Seiz-Rosenhagen, D. Hänggi, V. Hans, S. Rozsnoki, J. Hansford, P. Kohlhof, B. Kristensen, M. Lechner, Beatriz Lopes, C. Mawrin, R. Ketter, A. Kulozik, Z. Khatib, F. Heppner, A. Koch, A. Jouvet, C. Keohane, H. Mühleisen, W. Müller, U. Pohl, M. Prinz, A. Benner, M. Zapatka, N. Gottardo, P. Driever, C. Kramm, H. Müller, S. Rutkowski, K. Hoff, M. Frühwald, A. Gnekow, G. Fleischhack, S. Tippelt, G. Calaminus, C. Monoranu, A. Perry, Chris Jones, T. Jacques, B. Radlwimmer, M. Gessi, T. Pietsch, J. Schramm, G. Schackert, M. Westphal, G. Reifenberger, P. Wesseling, M. Weller, V. Collins, I. Blümcke, M. Bendszus, J. Debus, A. Huang, N. Jabado, P. Northcott, W. Paulus, A. Gajjar, G. Robinson, Michael D. Taylor, Z. Jaunmuktane, M. Ryzhova, M. Platten, A. Unterberg, W. Wick, M. Karajannis, M. Mittelbronn, T. Acker, C. Hartmann, K. Aldape, U. Schüller, R. Buslei, P. Lichter, M. Kool, C. Herold‐Mende, D. Ellison, M. Hasselblatt, M. Snuderl, S. Brandner, A. Korshunov, A. Deimling, S. Pfister   +142 more
semanticscholar   +1 more source

Dynamics of DNA Methylation and Its Functions in Plant Growth and Development

Frontiers in Plant Science, 2021
Epigenetic modifications in DNA bases and histone proteins play important roles in the regulation of gene expression and genome stability. Chemical modification of DNA base (e.g., addition of a methyl group at the fifth carbon of cytosine residue ...
Suresh Kumar, T. Mohapatra
semanticscholar   +1 more source

Inhibitors of DNA Methylation

, 2022
DNA methylation is involved in numerous biological processes and is deregulated in human diseases. The modulation of the activity of the enzymes and proteins in charge of DNA methylation, for example, DNA methyltransferases (DNMTs), can represent a powerful strategy to alter DNA methylation patterns and restore biological processes that are aberrant in
Lopez, Marie, Gilbert, Julie, Contreras, Jean, Halby, Ludovic, Arimondo, Paola B   +4 more
openaire   +3 more sources

DNA Methylation and Differentiation [PDF]

Environmental Health Perspectives, 1989
The methylation of specific cytosine residues in DNA has been implicated in regulating gene expression and facilitating functional specialization of cellular phenotypes. Generally, the demethylation of certain CpG sites correlates with transcriptional activation of genes.
Lesley A. Michalowsky, Peter A. Jones
openaire   +4 more sources

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
core   +1 more source

Predictors and consequences of global DNA methylation in cord blood and at three years. [PDF]

PLoS ONE, 2013
DNA methylation changes have been implicated in many common chronic diseases leading to the hypothesis that environmental and age-related DNA methylation changes within individuals are involved in disease etiology.
Julie B Herbstman, Shuang Wang, Frederica P Perera, Sally A Lederman, Julia Vishnevetsky, Andrew G Rundle, Lori A Hoepner, Lirong Qu, Deliang Tang   +8 more
doaj   +1 more source

Minimal evidence for consistent changes in maize DNA methylation patterns following environmental stress.

Frontiers in Plant Science, 2015
DNA methylation is a chromatin modification that is sometimes associated with epigenetic regulation of gene expression. As DNA methylation can be reversible at some loci, it is possible that methylation patterns may change within an organism that is ...
Steven R Eichten, Nathan M Springer
doaj   +1 more source

DNA methylation GrimAge strongly predicts lifespan and healthspan

Aging, 2019
It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan.
A. Lu, Austin Quach, James G. Wilson, A. Reiner, A. Aviv, K. Raj, L. Hou, A. Baccarelli, Yun Li, J. Stewart, E. Whitsel, T. Assimes, L. Ferrucci, S. Horvath   +13 more
semanticscholar   +1 more source

Sex-specific variations in global DNA methylation levels with age: a population-based exploratory study from North India

Frontiers in Genetics, 2023
Purpose: Aging is one of the most important risk factors for a number of human diseases. Epigenetic alterations, including changes in DNA methylation patterns, have been reported to be one of the hallmarks of aging. Being a malleable process, the role of
Anshika Kaushik, Vineet Chaudhary, Imnameren Longkumer, Kallur Nava Saraswathy, Sonal Jain   +4 more
doaj   +1 more source

DNA methylation and cancer [PDF]

Oncogene, 2002
There is tremendous ferment in the field of epigenetics as the relationships between chromatin structure and DNA methylation patterns become clearer. Central to this activity is the realization that the 'histone code', which involves the post-translational modification of histones and which has important ramifications for chromatin structure, may be ...
openaire   +5 more sources