Results 31 to 40 of about 382,011 (287)
Frontiers in Chemistry, 2023 DNA methylation plays an important physiological function in cells, and environmental changes result in fluctuations in DNA methylation levels. Metal ions have become both environmental and health concerns, as they have the potential to disrupt the ...
Shan Liu +4 more
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Role of genetic and environmental factors in DNA methylation of lipid metabolism
Genes and Diseases, 2018 A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate ...
Zhen He +4 more
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Parenting stress and DNA methylation among African Americans in the InterGEN Study
Journal of Clinical and Translational Science, 2017 IntroductionGeneral life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described.
Michelle L. Wright +6 more
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Regulated DNA Methylation and the Circadian Clock: Implications in Cancer
Biology, 2014 Since the cloning and discovery of DNA methyltransferases (DNMT), there has been a growing interest in DNA methylation, its role as an epigenetic modification, how it is established and removed, along with the implications in development and disease.
Tammy M. Joska +2 more
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DNA methylation and cancer [PDF]
Oncogene, 2002 There is tremendous ferment in the field of epigenetics as the relationships between chromatin structure and DNA methylation patterns become clearer. Central to this activity is the realization that the 'histone code', which involves the post-translational modification of histones and which has important ramifications for chromatin structure, may be ...
openaire +3 more sources
PLoS Genetics, 2020 Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa that ...
Fredrika Åsenius +9 more
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Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns
Frontiers in Microbiology, 2021 DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by transferring a methyl group to DNA. The genetic variation in DNMTs results in differential DNA methylation patterns associated with various biological processes.
Yu-Shin Nai +6 more
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Nature CommunicationsDNA methylation is an epigenetic mark that plays a critical role in regulating gene expression. DNA methyltransferase (DNMT) inhibitors, inhibit global DNA methylation and have been a key tool in studies of DNA methylation. A major bottleneck is the lack
Mahnaz Hosseinpour +13 more
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eLife, 2017 DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA methylation are known, relatively little is understood about how DNA methylation influences gene ...
Dongming Li +20 more
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