Results 51 to 60 of about 2,686,549 (398)
, 2023 DNA methylation, one of the most studied epigenetic modifications, refers to the addition of a methyl group to the fifth carbon of cytosine (C) catalyzed by DNA methyltransferases(Dnmts), forming 5-methylcytosine (5mC). DNA methylation predominantly occurs inCpGs but is also found in non-CpG contexts.
openaire +3 more sources
BioTechniques, 2015 Variations in DNA methylation have been implicated in a number of disorders. Changes in global DNA methylation levels have long been associated with various types of cancer.
Elif Aysimi Duman +3 more
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PLoS Genetics, 2020 Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa that ...
Fredrika Åsenius +9 more
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Diversity of Fungal DNA Methyltransferases and Their Association With DNA Methylation Patterns
Frontiers in Microbiology, 2021 DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by transferring a methyl group to DNA. The genetic variation in DNMTs results in differential DNA methylation patterns associated with various biological processes.
Yu-Shin Nai +6 more
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Parenting stress and DNA methylation among African Americans in the InterGEN Study
Journal of Clinical and Translational Science, 2017 IntroductionGeneral life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described.
Michelle L. Wright +6 more
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Frontiers in Genetics, 2023 Purpose: Aging is one of the most important risk factors for a number of human diseases. Epigenetic alterations, including changes in DNA methylation patterns, have been reported to be one of the hallmarks of aging. Being a malleable process, the role of
Anshika Kaushik +4 more
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Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. [PDF]
PLoS ONE, 2015 Recent studies have implicated epigenetics in the pathophysiology of diabetes. Furthermore, DNA methylation, which irreversibly deactivates gene transcription, of the insulin promoter, particularly the cAMP response element, is increased in diabetes ...
Kota Ishikawa +14 more
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DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with Ulcerative Colitis (UC) [PDF]
, 2010 Introduction: Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures.
Arasaradnam, Ramesh P. +4 more
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Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. [PDF]
PLoS Genetics, 2008 At the imprinted Rasgrf1 locus in mouse, a cis-acting sequence controls DNA methylation at a differentially methylated domain (DMD). While characterizing epigenetic marks over the DMD, we observed that DNA and H3K27 trimethylation are mutually exclusive,
Anders M Lindroth +11 more
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Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research [PDF]
, 2011 Epigenetics is the study of all mechanisms that regulate gene transcription and genome stability that are maintained throughout the cell division, but do not include the DNA sequence itself.
A Hellman +50 more
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