Results 51 to 60 of about 2,392,207 (383)
Frontiers in Plant Science, 2015 DNA methylation is a chromatin modification that is sometimes associated with epigenetic regulation of gene expression. As DNA methylation can be reversible at some loci, it is possible that methylation patterns may change within an organism that is ...
Steven R Eichten, Nathan M Springer
doaj +1 more source
Frontiers in Genetics, 2023 Purpose: Aging is one of the most important risk factors for a number of human diseases. Epigenetic alterations, including changes in DNA methylation patterns, have been reported to be one of the hallmarks of aging. Being a malleable process, the role of
Anshika Kaushik +4 more
doaj +1 more source
Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements [PDF]
, 2013 Background: Recent assays for individual-specific genome-wide DNA methylation profiles have enabled epigenome-wide association studies to identify specific CpG sites associated with a phenotype. Computational prediction of CpG site-specific methylation levels is important, but current approaches tackle average methylation within a genomic locus and are
arxiv +1 more source
Long-term pancreatic beta cell exposure to high levels of glucose but not palmitate induces DNA methylation within the insulin gene promoter and represses transcriptional activity. [PDF]
PLoS ONE, 2015 Recent studies have implicated epigenetics in the pathophysiology of diabetes. Furthermore, DNA methylation, which irreversibly deactivates gene transcription, of the insulin promoter, particularly the cAMP response element, is increased in diabetes ...
Kota Ishikawa +14 more
doaj +1 more source
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. [PDF]
PLoS Genetics, 2008 At the imprinted Rasgrf1 locus in mouse, a cis-acting sequence controls DNA methylation at a differentially methylated domain (DMD). While characterizing epigenetic marks over the DMD, we observed that DNA and H3K27 trimethylation are mutually exclusive,
Anders M Lindroth +11 more
doaj +1 more source
DNA methylation arrays as surrogate measures of cell mixture distribution
BMC Bioinformatics, 2012 There has been a long-standing need in biomedical research for a method that quantifies the normally mixed composition of leukocytes beyond what is possible by simple histological or flow cytometric assessments.
E. Houseman +7 more
semanticscholar +1 more source
Scientific Reports, 2021 Targeted DNA methylation is a technique that aims to methylate cytosines in selected genomic loci. In the most widely used approach a CG-specific DNA methyltransferase (MTase) is fused to a sequence specific DNA binding protein, which binds in the ...
Krystyna Ślaska-Kiss +6 more
doaj +1 more source
DNA methylation aging clocks: challenges and recommendations
Genome Biology, 2019 Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed
C. Bell +20 more
semanticscholar +1 more source
Methylation of chromatin DNA [PDF]
Nucleic Acids Research, 1976 E. coli DNA methylase has been used to methylate chromatin DNA in vitro. At saturation only 50% of the chromatin DNA becomes methylated. The methylated regions of chromatin correspond to that fraction of the chromatin which is sensitive to staphylococcal nuclease.
Howard Cedar, Shoshana Bloch
openaire +2 more sources
Regulated DNA Methylation and the Circadian Clock: Implications in Cancer
Biology, 2014 Since the cloning and discovery of DNA methyltransferases (DNMT), there has been a growing interest in DNA methylation, its role as an epigenetic modification, how it is established and removed, along with the implications in development and disease.
Tammy M. Joska +2 more
doaj +1 more source