Results 61 to 70 of about 2,768,548 (336)

DNA methylation aging clocks: challenges and recommendations

Genome Biology, 2019
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed
C. Bell, R. Lowe, P. Adams, A. Baccarelli, S. Beck, J. Bell, B. Christensen, V. Gladyshev, B. Heijmans, S. Horvath, T. Ideker, J. Issa, K. Kelsey, R. Marioni, W. Reik, C. Relton, L. Schalkwyk, A. Teschendorff, W. Wagner, Kang Zhang, V. Rakyan   +20 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Interleukin-6 accelerates the progression of warm autoimmune hemolytic anemia by affecting the DNA methylation status of peripheral blood B lymphocytes

Scientific Reports
DNA methylation of peripheral blood (PB) B cells of warm autoimmune hemolytic anemia (wAIHA) patient was investigated. B cell DNA methylation level and the methylation-regulatory genes mRNA from 34 wAIHA patients and 16 healthy controls (HCs) were ...
Manjun Zhao, Yang Zhang, Zhaoyun Liu, Rong Fu, Huaquan Wang, Zonghong Shao, Limin Xing   +6 more
doaj   +1 more source

Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. [PDF]

PLoS Genetics, 2008
At the imprinted Rasgrf1 locus in mouse, a cis-acting sequence controls DNA methylation at a differentially methylated domain (DMD). While characterizing epigenetic marks over the DMD, we observed that DNA and H3K27 trimethylation are mutually exclusive,
Anders M Lindroth, Yoon Jung Park, Chelsea M McLean, Gregoriy A Dokshin, Jenna M Persson, Herry Herman, Diego Pasini, Xavier Miró, Mary E Donohoe, Jeannie T Lee, Kristian Helin, Paul D Soloway   +11 more
doaj   +1 more source

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The pivotal role of DNA methylation in the radio‐sensitivity of tumor radiotherapy

Cancer Medicine, 2018
Radiotherapy is an important modality for treatment of carcinomas; however, radio‐resistance is still a difficult problem. Aberrant epigenetic alterations play an important role in cancer development.
Xueru Zhu, Yiting Wang, Li Tan, Xiaolong Fu   +3 more
doaj   +1 more source

Lowering DNA binding affinity of SssI DNA methyltransferase does not enhance the specificity of targeted DNA methylation in E. coli

Scientific Reports, 2021
Targeted DNA methylation is a technique that aims to methylate cytosines in selected genomic loci. In the most widely used approach a CG-specific DNA methyltransferase (MTase) is fused to a sequence specific DNA binding protein, which binds in the ...
Krystyna Ślaska-Kiss, Nikolett Zsibrita, Mihály Koncz, Pál Albert, Ákos Csábrádi, Sarolta Szentes, Antal Kiss   +6 more
doaj   +1 more source

DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with Ulcerative Colitis (UC) [PDF]

, 2010
Introduction: Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures.
Arasaradnam, Ramesh P., Bradburn, Mike, Kelly, S. B., Khoo, K. T. J., Mathers, John C.   +4 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source