Results 181 to 190 of about 70,351 (245)

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Causes of DNA mismatch repair deficiency in sebaceous skin lesions demonstrating loss of MLH1 protein expression: constitutional over somatic MLH1 promoter methylation. [PDF]

Fam Cancer
Joo JE, Mahmood K, Clendenning M, Walker R, Georgeson P, Como J, Jenkins MA, Walsh MD, Winship IM, Buchanan DD.   +9 more
europepmc   +1 more source

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

iMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I. Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang, Kewei Fan, Xiaole Yin, Hein Min Tun, Renyou Gan, Haichong Wu, Qi Su   +15 more
wiley   +1 more source

Mountains Without Borders: Scaling up Conservation Success for Snow Leopards

Integrative Conservation, EarlyView.
This special issue assembles pioneering research addressing three critical and interconnected challenges: establishing where viable populations persist at range edges, advancing methods to monitor this cryptic species and its prey effectively, and evaluating whether landscapes remain connected across political boundaries.
Juan Li, Lingyun Xiao
wiley   +1 more source

Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis. [PDF]

Front Immunol
Zhang H, Huang J, Xu H, Yin N, Zhou L, Xue J, Ren M.   +6 more
europepmc   +1 more source

From mechanism to phenotype: What fits in a basket trial

Epilepsia, EarlyView.
Kette D. Valente
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Mycobacterium smegmatis NucS-promoted DNA mismatch repair involves limited resection by a 5'-3' exonuclease and is independent of homologous recombination and NHEJ. [PDF]

Nucleic Acids Res
Rivera-Flores IV, Wang EX, Murphy KC.
europepmc   +1 more source

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

Interdisciplinary Medicine, EarlyView.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun   +10 more
wiley   +1 more source

MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma. [PDF]

Acta Neuropathol
Friker LL, Perwein T, Waha A, Dörner E, Klein R, Blattner-Johnson M, Layer JP, Sturm D, Nussbaumer G, Kwiecien R, Spier I, Aretz S, Kerl K, Hennewig U, Rohde M, Karow A, Bluemcke I, Schmitz AK, Reinhard H, Hernáiz Driever P, Wendt S, Weiser A, Guerreiro Stücklin AS, Gerber NU, von Bueren AO, Khurana C, Jorch N, Wiese M, Kratz CP, Eyrich M, Karremann M, Herrlinger U, Hölzel M, Jones DTW, Hoffmann M, Pietsch T, Gielen GH, Kramm CM.   +37 more
europepmc   +1 more source