Results 251 to 260 of about 297,565 (330)

Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis. [PDF]

Front Immunol
Zhang H, Huang J, Xu H, Yin N, Zhou L, Xue J, Ren M.   +6 more
europepmc   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency. [PDF]

J Natl Cancer Inst
Fang A, Ugai T, Gurjao C, Zhong R, Liu Z, Zhang X, Wang P, Nowak J, Wang M, Giannakis M, Ogino S, Zhang X, Giovannucci E.   +12 more
europepmc   +1 more source

Whole tissue imaging of cellular boundaries at sub‐micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm

Developmental Dynamics, EarlyView.
Abstract Background To understand cellular morphology, biologists have relied on traditional optical microscopy of tissues combined with tissue clearing protocols to image structures deep within tissues. Unfortunately, these protocols often struggle to retain cell boundary markers, especially at high enough resolutions necessary for precise cell ...
Sam C. P. Norris, Jimmy K. Hu, Neil H. Shubin   +2 more
wiley   +1 more source

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

Cell, 1996
A. Umar, A. Buermeyer, J. Simon, David C. Thomas, A. Clark, R. Liskay, T. Kunkel   +6 more
semanticscholar   +1 more source

Trends in marine species distribution models: a review of methodological advances and future challenges

Ecography, EarlyView.
Correlative species distribution models (SDMs) are quantitative tools in biogeography and macroecology. Building upon the ecological niche concept, they correlate environmental covariates to species presence to model habitat suitability and predict species distributions.
Moritz Klaassen, Tiago A. Marques, Filipe Alves, Marc Fernandez   +3 more
wiley   +1 more source

Mycobacterium smegmatis NucS-promoted DNA mismatch repair involves limited resection by a 5'-3' exonuclease and is independent of homologous recombination and NHEJ. [PDF]

Nucleic Acids Res
Rivera-Flores IV, Wang EX, Murphy KC.
europepmc   +1 more source

Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer.

New England Journal of Medicine, 2006
R. Barnetson, A. Tenesa, S. Farrington, I. Nicholl, R. Cetnarskyj, M. Porteous, H. Campbell, M. Dunlop   +7 more
semanticscholar   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Effect of Henan and Gansu Starter Cultures Microbial Diversity on Structure and Flavor Property of Mung Bean Bread

Food Frontiers, EarlyView.
ABSTRACT This study examined the fermentation mechanism of Gansu starter cultures (GSSC) and Henan starter cultures (HNSC), each mixed with yeast, in enhancing the distinctive flavor of bread. High‐throughput sequencing analysis revealed that 157 bacterial genera and 53 fungal genera were identified in the GSSC, while the HNSC comprised 29 bacterial ...
Xiaoming Wang, Xiling Zhang, Lu Kong, Weichao Guan, Chanmin Zheng, Dan Yang, Guoqi Na, Chenqi Gu, Qingyu Yang, Yuguang Zhang   +9 more
wiley   +1 more source