Results 41 to 50 of about 2,971,475 (254)
PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells [PDF]
, 2011 Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis.
Geacintov, Nicholas E. +47 more
core +2 more sources
Analysis of 8-oxo-7, 8-dihydroGuanine formation and oxidation mediated by Fenton reaction induced DNA oxidative stress [PDF]
, 2005 DNA undergoes an estimated 10,000 oxidative hits per day. Oxidative DNA damage caused by reactive oxygen species (ROS) can result in multiple base modifications, which have been implicated in mutagenesis, disease and aging.
White, Blánaid
core +2 more sources
Crosstalk between epigenetic modification and circRNA in colorectal cancer: recent advances
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Colorectal cancer (CRC) is generally regarded as the third frequent malignancy worldwide, while current diagnosis and treatment of the disease are limited.
PENG Tian, XU Leiming
doaj +1 more source
Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA. [PDF]
PLoS Genetics, 2010 Many taxonomically diverse prokaryotes enzymatically modify their DNA by replacing a non-bridging oxygen with a sulfur atom at specific sequences. The biological implications of this DNA S-modification (phosphorothioation) were unknown.
Guang Liu +8 more
doaj +1 more source
The terminal redundant regions of bacteriophage T7 DNA: their necessity for phage production studied by the infectivity of T7 DNA after modification by various exonucleases [PDF]
, 1978 Dreiseikelmann B, Wackernagel W. The terminal redundant regions of bacteriophage T7 DNA: their necessity for phage production studied by the infectivity of T7 DNA after modification by various exonucleases. Molecular and General Genetics. 1978;159(3):321-
Dreiseikelmann, Brigitte +1 more
core +1 more source
Mapping the epigenetic modifications of DNA and RNA
Protein & Cell, 2020 Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and ...
Lin-Yong Zhao +4 more
doaj +1 more source
Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine +17 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani +7 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
BMC Biology, 2004 Background In mammals, there is evidence suggesting that methyl-CpG binding proteins may play a significant role in histone modification through their association with modification complexes that can deacetylate and/or methylate nucleosomes in the ...
Canfield Theresa K +6 more
doaj +1 more source