Results 21 to 30 of about 743,722 (313)
A novel DNA modification by sulphur [PDF]
Molecular Microbiology, 2005 SummaryStreptomyces lividans has a novel DNA modification, which sensitises its DNA to degradation during electrophoresis (the Dnd phenotype). The entire gene cluster (dnd) involved in this modification was localized on an 8 kb DNA fragment and was expressed in a S. lividans deletion mutant (dnd) and in several heterologous hosts. Disruption of the dnd
Xiufen, Zhou +7 more
openaire +2 more sources
A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]
, 2013 The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core +1 more source
Frontiers in Oncology, 2021 BackgroundEpigenetic changes of lung adenocarcinoma (LUAD) have been reported to be a relevant factor in tumorigenesis and cancer progression. However, the molecular mechanisms responsible for DNA methylation patterns in the tumor immune-infiltrating ...
Didi Yuan +8 more
doaj +1 more source
Biomolecular Concepts, 2015 The glyoxalase enzyme system utilizes intracellular thiols such as glutathione to convert α-ketoaldehydes, such as methylglyoxal, into D-hydroxyacids. This overview discusses several main aspects of the glyoxalase system and its likely function in the ...
Honek John F.
doaj +1 more source
Impact of target site distribution for Type I restriction enzymes on the evolution of methicillin-resistant Staphylococcus aureus (MRSA) populations. [PDF]
, 2013 A limited number of Methicillin-resistant Staphylococcus aureus (MRSA) clones are responsible for MRSA infections worldwide, and those of different lineages carry unique Type I restriction-modification (RM) variants.
Dryden, David T. F. +15 more
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Frontiers in Genetics, 2022 Emerging evidence implies a non-negligible role of DNA methylation in tumor immunity, however, its comprehensive impact on tumor microenvironment (TME) formation and immune activation remains unclear.
Shijin Yuan +4 more
doaj +1 more source
DNA Modifications and Neurological Disorders [PDF]
Neurotherapeutics, 2013 Mounting evidence has recently underscored the importance of DNA methylation in normal brain functions. DNA methylation machineries are responsible for dynamic regulation of methylation patterns in discrete brain regions. In addition to methylation of cytosines in genomic DNA (5-methylcytosine; 5mC), other forms of modified cytosines, such as 5 ...
Yi-Lan, Weng +4 more
openaire +2 more sources
PLoS Genetics, 2022 Understanding mechanisms that shape horizontal exchange in prokaryotes is a key problem in biology. A major limit on DNA entry is imposed by restriction-modification (RM) processes that depend on the pattern of DNA modification at host-specified sites ...
Julie Zaworski +6 more
doaj +1 more source
Regulation of dndB Gene Expression in Streptomyces lividans
Frontiers in Microbiology, 2018 DNA sulfur modification is a unique modification occurring in the sugar-phosphate backbone of DNA, with a nonbridging oxygen atom substituted with sulfur in a sequence-specific and Rp stereo-specific manner.
Daofeng Dai +4 more
doaj +1 more source
Zinc finger recombinases with adaptable DNA sequence specificity [PDF]
, 2011 Site-specific recombinases have become essential tools in genetics and molecular biology for the precise excision or integration of DNA sequences. However, their utility is currently limited to circumstances where the sites recognized by the recombinase ...
Proudfoot, C. +19 more
core +1 more source