Results 21 to 30 of about 716,957 (263)
Frontiers in Genetics, 2022 Emerging evidence implies a non-negligible role of DNA methylation in tumor immunity, however, its comprehensive impact on tumor microenvironment (TME) formation and immune activation remains unclear.
Shijin Yuan +4 more
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PLoS Genetics, 2022 Understanding mechanisms that shape horizontal exchange in prokaryotes is a key problem in biology. A major limit on DNA entry is imposed by restriction-modification (RM) processes that depend on the pattern of DNA modification at host-specified sites ...
Julie Zaworski +6 more
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Playing TETris with DNA modifications [PDF]
The EMBO Journal, 2014 Methylation of the fifth carbon of cytosine was the first epigenetic modification to be discovered in DNA. Recently, three new DNA modifications have come to light: hydroxymethylcytosine, formylcytosine, and carboxylcytosine, all generated by oxidation of methylcytosine by Ten Eleven Translocation (TET) enzymes.
Delatte, Benjamin +2 more
openaire +3 more sources
DNA Modifications and Neurological Disorders [PDF]
Neurotherapeutics, 2013 Mounting evidence has recently underscored the importance of DNA methylation in normal brain functions. DNA methylation machineries are responsible for dynamic regulation of methylation patterns in discrete brain regions. In addition to methylation of cytosines in genomic DNA (5-methylcytosine; 5mC), other forms of modified cytosines, such as 5 ...
Yi-Lan, Weng +4 more
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Regulation of dndB Gene Expression in Streptomyces lividans
Frontiers in Microbiology, 2018 DNA sulfur modification is a unique modification occurring in the sugar-phosphate backbone of DNA, with a nonbridging oxygen atom substituted with sulfur in a sequence-specific and Rp stereo-specific manner.
Daofeng Dai +4 more
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Molecular Therapy: Nucleic Acids, 2021 Growing evidence implies a link between DNA methylation and tumor immunity/immunotherapy. However, the global influence of DNA methylation on the characteristics of the tumor microenvironment and the efficacy of immunotherapy remains to be clarified.
Qi Meng +10 more
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Scientific Reports, 2017 DNA phosphorothioate (PT) modification is a sulfur modification on the backbone of DNA introduced by the proteins DndA-E. It has been detected within many bacteria isolates and metagenomic datasets, including human pathogens, and is considered to be ...
Yan Yang +9 more
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BMC Genomics, 2011 Background In parallel with the quick development of high-throughput technologies, in vivo (vitro) experiments for genome-wide identification of protein-DNA interactions have been developed.
Wang Junbai
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Identifying DNA methylation in a nanochannel
Science and Technology of Advanced Materials, 2016 DNA methylation is a stable epigenetic modification, which is well known to be involved in gene expression regulation. In general, however, analyzing DNA methylation requires rather time consuming processes (24–96 h) via DNA replication and protein ...
Xiaoyin Sun +8 more
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Functions of PARylation in DNA Damage Repair Pathways
Genomics, Proteomics & Bioinformatics, 2016 Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs).
Huiting Wei, Xiaochun Yu
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