Results 31 to 40 of about 743,722 (313)
Scientific Reports, 2017 DNA phosphorothioate (PT) modification is a sulfur modification on the backbone of DNA introduced by the proteins DndA-E. It has been detected within many bacteria isolates and metagenomic datasets, including human pathogens, and is considered to be ...
Yan Yang +9 more
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BMC Genomics, 2011 Background In parallel with the quick development of high-throughput technologies, in vivo (vitro) experiments for genome-wide identification of protein-DNA interactions have been developed.
Wang Junbai
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Molecular Therapy: Nucleic Acids, 2021 Growing evidence implies a link between DNA methylation and tumor immunity/immunotherapy. However, the global influence of DNA methylation on the characteristics of the tumor microenvironment and the efficacy of immunotherapy remains to be clarified.
Qi Meng +10 more
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Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]
, 2007 Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
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PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells [PDF]
, 2011 Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis.
Geacintov, Nicholas E. +47 more
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Identifying DNA methylation in a nanochannel
Science and Technology of Advanced Materials, 2016 DNA methylation is a stable epigenetic modification, which is well known to be involved in gene expression regulation. In general, however, analyzing DNA methylation requires rather time consuming processes (24–96 h) via DNA replication and protein ...
Xiaoyin Sun +8 more
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Functions of PARylation in DNA Damage Repair Pathways
Genomics, Proteomics & Bioinformatics, 2016 Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs).
Huiting Wei, Xiaochun Yu
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VEZF1 elements mediate protection from DNA methylation [PDF]
, 2010 There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
Gowher Humaira +21 more
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Calibrating catalytic DNA nanostructures for site-selective protein modification
, 2022 Many biomedical fields rely on proteins that are selectively modified with novel chemical entities. These are often attached using reactive or catalytic moieties, but the position where these moieties are attached is often poorly controlled. In this work,
HB, Albada, Jordi, Keijzer, Han, Zuilhof
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, 2008 Digestion patterns of chromosomal DNAs of Bacillus cereus and Bacillus weihenstephanensis strains suggest that Sau3AI-type restriction modification systems are widely present among the isolates tested.
Abee, T. +5 more
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