Results 31 to 40 of about 1,176,556 (303)
Frontiers in Genetics, 2022 Emerging evidence implies a non-negligible role of DNA methylation in tumor immunity, however, its comprehensive impact on tumor microenvironment (TME) formation and immune activation remains unclear.
Shijin Yuan +4 more
doaj +1 more source
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. [PDF]
, 2009 Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling DNA repair and apoptosis are well characterized, the precise molecular ...
Cook, Peter J +5 more
core +2 more sources
DNA Modifications and Neurological Disorders [PDF]
Neurotherapeutics, 2013 Mounting evidence has recently underscored the importance of DNA methylation in normal brain functions. DNA methylation machineries are responsible for dynamic regulation of methylation patterns in discrete brain regions. In addition to methylation of cytosines in genomic DNA (5-methylcytosine; 5mC), other forms of modified cytosines, such as 5 ...
Yi-Lan, Weng +4 more
openaire +2 more sources
AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication, transcription and chromatin remodeling [PDF]
, 2015 Background: DNA replication and transcription are dynamic processes regulating plant development that are dependent on the chromatin accessibility. Proteins belonging to the Agenet/Tudor domain family are known as histone modification "readers" and ...
Barroso-Neto, Ito Liberato +9 more
core +3 more sources
Regulation of dndB Gene Expression in Streptomyces lividans
Frontiers in Microbiology, 2018 DNA sulfur modification is a unique modification occurring in the sugar-phosphate backbone of DNA, with a nonbridging oxygen atom substituted with sulfur in a sequence-specific and Rp stereo-specific manner.
Daofeng Dai +4 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 Growing evidence implies a link between DNA methylation and tumor immunity/immunotherapy. However, the global influence of DNA methylation on the characteristics of the tumor microenvironment and the efficacy of immunotherapy remains to be clarified.
Qi Meng +10 more
doaj +1 more source
Scientific Reports, 2017 DNA phosphorothioate (PT) modification is a sulfur modification on the backbone of DNA introduced by the proteins DndA-E. It has been detected within many bacteria isolates and metagenomic datasets, including human pathogens, and is considered to be ...
Yan Yang +9 more
doaj +1 more source
Enhanced transformation efficiency of recalcitrant Bacillus cereus and Bacillus weihenstephanensis isolates upon in vitro methylation of plasmid DNA [PDF]
, 2008 Digestion patterns of chromosomal DNAs of Bacillus cereus and Bacillus weihenstephanensis strains suggest that Sau3AI-type restriction modification systems are widely present among the isolates tested.
Nierop Groot, M.N. +2 more
core +1 more source
DNA-Mediated Electron Transfer in Naphthalene-Modified Oligonucleotides [PDF]
, 2010 Naphthalene-modified oligonucleotides have been synthesized and characterized with respect to electron transfer chemistry. Using the Sonogashira coupling reaction, naphthalene can be covalently anchored onto a modified uridine through an ethynyl linkage.
Barton, Jacqueline K. +2 more
core +3 more sources
DNA modifications in the mammalian brain [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 DNA methylation is a crucial epigenetic mark in mammalian development, genomic imprinting, X-inactivation, chromosomal stability and suppressing parasitic DNA elements. DNA methylation in neurons has also been suggested to play important roles for mammalian neuronal functions, and learning and memory.
Jaehoon, Shin +2 more
openaire +2 more sources