Results 31 to 40 of about 716,957 (263)
Chromatin modification by DNA tracking [PDF]
Proceedings of the National Academy of Sciences, 1999 In general, the transcriptional competence of a chromatin domain is correlated with increased sensitivity to DNase I cleavage. A recent observation that actively transcribing RNA polymerase II piggybacks a histone acetyltranferase activity [Wittschieben, B., Otero, G., de Bizemont, T., Fellows, J., Erdjument-Bromage, H., Ohba, R ...
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Crosstalk between epigenetic modification and circRNA in colorectal cancer: recent advances
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Colorectal cancer (CRC) is generally regarded as the third frequent malignancy worldwide, while current diagnosis and treatment of the disease are limited.
PENG Tian, XU Leiming
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Mapping the epigenetic modifications of DNA and RNA
Protein & Cell, 2020 Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and ...
Lin-Yong Zhao +4 more
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Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA. [PDF]
PLoS Genetics, 2010 Many taxonomically diverse prokaryotes enzymatically modify their DNA by replacing a non-bridging oxygen with a sulfur atom at specific sequences. The biological implications of this DNA S-modification (phosphorothioation) were unknown.
Guang Liu +8 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
Quantification and mapping of DNA modifications
RSC Chemical Biology, 2021 Apart from the four canonical nucleobases, DNA molecules carry a number of natural modifications.
Yi Dai, Bi-Feng Yuan, Yu-Qi Feng
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan +1 more
wiley +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
BMC Biology, 2004 Background In mammals, there is evidence suggesting that methyl-CpG binding proteins may play a significant role in histone modification through their association with modification complexes that can deacetylate and/or methylate nucleosomes in the ...
Canfield Theresa K +6 more
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Human Genomics, 2020 5-Methylcytosine (5mC) is considered as a common epigenetic modification that plays an important role in the regulation of gene expression. At the same time, 5-hydroxymethylcytosine (5hmC) has been found as an emerging modification of cytosine bases of ...
Tianmin Xu, Haoyue Gao
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