Results 51 to 60 of about 1,176,556 (303)
Elevated Level of DNA Damage and Impaired Repair of Oxidative DNA Damage in Patients with Recurrent Depressive Disorder [PDF]
, 2015 Background: Depressive disorder (DD), including recurrent DD (rDD), is a severe psychological disease, which affects a large percentage of the world population.
Bielecka-Kowalska, Anna +9 more
core +1 more source
Dissociation of single-stranded DNA from nucleosomes following modification with acetic anhydride [PDF]
, 2013 Modification with acetic anhydride of nucleosomes from chicken erythrocytes at low ionic strength (less than 0.1 M NaCl) is accompanied by the formation of residual particles and the release of free DNA. This DNA has been identified as single-stranded by
Jordano, Juan +2 more
core +2 more sources
Quantification and mapping of DNA modifications
RSC Chemical Biology, 2021 Apart from the four canonical nucleobases, DNA molecules carry a number of natural modifications.
Yi Dai, Bi-Feng Yuan, Yu-Qi Feng
openaire +3 more sources
Mapping the epigenetic modifications of DNA and RNA
Protein & Cell, 2020 Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and ...
Lin-Yong Zhao +4 more
doaj +1 more source
Monte Carlo simulation of melting transition on DNA nanocompartment
, 2005 DNA nanocompartment is a typical DNA-based machine whose function is dependent of molecular collective effect. Fundamental properties of the device have been addressed via electrochemical analysis, fluorescent microscopy, and atomic force microscopy ...
Bard A J +6 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Human Genomics, 2020 5-Methylcytosine (5mC) is considered as a common epigenetic modification that plays an important role in the regulation of gene expression. At the same time, 5-hydroxymethylcytosine (5hmC) has been found as an emerging modification of cytosine bases of ...
Tianmin Xu, Haoyue Gao
doaj +1 more source
DNA Epigenetics in Addiction Susceptibility
Frontiers in Genetics, 2022 Addiction is a chronically relapsing neuropsychiatric disease that occurs in some, but not all, individuals who use substances of abuse. Relatively little is known about the mechanisms which contribute to individual differences in susceptibility to ...
Graham Kaplan +3 more
doaj +1 more source
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2013 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Ahmed +38 more
core +2 more sources
BMC Biology, 2004 Background In mammals, there is evidence suggesting that methyl-CpG binding proteins may play a significant role in histone modification through their association with modification complexes that can deacetylate and/or methylate nucleosomes in the ...
Canfield Theresa K +6 more
doaj +1 more source