Results 11 to 20 of about 43,846 (273)
Acceleration of DNA Replication of Klenow Fragment by Small Resisting Force [PDF]
Chin. Phys. Lett. 2021, 38 (11): 118701, 2021 DNA polymerases are an essential class of enzymes or molecular motors that catalyze processive DNA syntheses during DNA replications. A critical issue for DNA polymerases is their molecular mechanism of processive DNA replication. We have previously proposed a model for chemomechanical coupling of DNA polymerases, based on which the predicted results ...
arxiv +1 more source
Accessibility of DNA in Chromatin to DNA Polymerase and RNA Polymerase [PDF]
Proceedings of the National Academy of Sciences, 1973 The accessibility of DNA in chromatin to both exogenous DNA polymerase and RNA polymerase is slight when compared to isolated DNA. DNA in extracted chromatin is somewhat more accessible to these enzymes than is DNA in the chromatin of isolated nuclei; and the DNA template of chromatin is more accessible to DNA polymerase than to RNA polymerase.
Bert Silverman, Alfred E. Mirsky
openaire +3 more sources
Replicative DNA Polymerases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 In 1959, Arthur Kornberg was awarded the Nobel Prize for his work on the principles by which DNA is duplicated by DNA polymerases. Since then, it has been confirmed in all branches of life that replicative DNA polymerases require a single-stranded template to build a complementary strand, but they cannot start a new DNA strand de novo.
Johansson, Erik, Dixon, Nicholas
openaire +4 more sources
The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box [PDF]
Open Biology, 2017 A dynamic multi-protein assembly known as the replisome is responsible for DNA synthesis in eukaryotic cells. In yeast, the hub protein Ctf4 bridges DNA helicase and DNA polymerase and recruits factors with roles in metabolic processes coupled to DNA ...
Mairi L. Kilkenny +5 more
doaj +1 more source
The DNA polymerases of Drosophila melanogaster
Fly, 2020 DNA synthesis during replication or repair is a fundamental cellular process that is catalyzed by a set of evolutionary conserved polymerases.
Steven J. Marygold +9 more
doaj +1 more source
Jurnal Kimia Sains dan Aplikasi, 2020 The search for novel DNA Polymerases I, with higher fidelity and better polymerization rate, is essential to improve the Polymerase Chain Reaction method.
Teuku Mohamad Iqbalsyah +3 more
doaj +1 more source
DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication
Viruses, 2021 Bacteriophages have long been model systems to study the molecular mechanisms of DNA replication. During DNA replication, a DNA helicase and a DNA polymerase cooperatively unwind the parental DNA.
Chen-Yu Lo, Yang Gao
doaj +1 more source
Biomolecules, 2019 Bacteriophage Phi29 DNA polymerase belongs to the protein-primed subgroup of family B DNA polymerases that use a terminal protein (TP) as a primer to initiate genome replication. The resolution of the crystallographic structure showed that it consists of
Alicia del Prado +4 more
doaj +1 more source
Density- and elongation speed-dependent error correction in RNA polymerization [PDF]
, 2021 Backtracking of RNA polymerase (RNAP) is an important pausing mechanism during DNA transcription that is part of the error correction process that enhances transcription fidelity. We model the backtracking mechanism of RNA polymerase, which usually happens when the polymerase tries to incorporate a mismatched nucleotide triphosphate.
arxiv +1 more source
Genes and Environment, 2022 Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf) exo− incorporated dATP opposite Ua, and that DNA polymerase β was blocked by Ua.
Taishu Kawada +8 more
doaj +1 more source