Results 11 to 20 of about 1,030,716 (269)

Discovery of cyanophage genomes which contain mitochondrial DNA polymerase [PDF]

, 2011
DNA polymerase γ is a family A DNA polymerase responsible for the replication of mitochondrial DNA in eukaryotes. The origins of DNA polymerase γ have remained elusive because it is not present in any known bacterium, though it has been hypothesized that
Whitworth, Anna L., Holmes, Antony B., Mohr, Remus, Hess, Wolfgang R., Nicholas H. Mann, David J. Scanlan, Remus Mohr, Scanlan, David J., Antony B. Holmes, Anthony W. Larkum, Martha R. J. Clokie, Clokie, Martha R. J., Anna L. Whitworth, Yi-Wah Chan, Millard, Andrew D., Wolfgang R. Hess, Mann, Nicholas H., Andrew D. Millard, Chan, Yi-Wah, Larkum, Anthony W. D.   +19 more
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The Loop of the TPR1 Subdomain of Phi29 DNA Polymerase Plays a Pivotal Role in Primer-Terminus Stabilization at the Polymerization Active Site

Biomolecules, 2019
Bacteriophage Phi29 DNA polymerase belongs to the protein-primed subgroup of family B DNA polymerases that use a terminal protein (TP) as a primer to initiate genome replication. The resolution of the crystallographic structure showed that it consists of
Alicia del Prado, Eugenia Santos, José M. Lázaro, Margarita Salas, Miguel de Vega   +4 more
doaj   +1 more source

dnaX36 mutator of Escherichia coli: effects of the tau subunit of the DNA polymerase III holoenzyme on chromosomal DNA replication fidelity. [PDF]

, 2011
The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded τ subunit of the DNA polymerase III (Pol III) holoenzyme.
Jonczyk, Piotr, Roel M. Schaaper, Gawel, Damian, Piotr Jonczyk, Damian Gawel, Fijalkowska, Iwona J., Schaaper, Roel, Iwona J. Fijalkowska   +7 more
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Mismatch repair in recombination of bacteriophage T4

Biomolecular Concepts, 2012
The review focuses on the mechanism of mismatch repair in bacteriophage T4. It was first observed in T4 as an extra recombination mechanism, which contributed to the general recombination only when particular rII mutations were used as genetic markers ...
Shcherbakov Victor P.
doaj   +1 more source

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]

, 2013
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G., Panov, Konstantin I; id_orcid, Zomerdijk, Joost C.B.M., Russell, J., Miller, G. (Gail), Zomerdijk, Joost C B M, Porter, A.C., Porter, Andrew C G, Volkov, A., Panov, K.I., Panov, Konstantin I., Russell, J. (Jackie), Panova, T., Zomerdijk, J.C., Miller, Gail, Porter, Andrew C.G., Miller, G., Panova, Tatiana, Russell, Jackie, Ray, S., Ray, Swagat, Volkov, Arsen, Zomerdijk, Joost C. B. M.   +22 more
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Analysis of nucleotide insertion opposite urea and translesion synthesis across urea by DNA polymerases

Genes and Environment, 2022
Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf) exo− incorporated dATP opposite Ua, and that DNA polymerase β was blocked by Ua.
Taishu Kawada, Katsuhito Kino, Kyousuke Tokorodani, Ryuto Anabuki, Masayuki Morikawa, Takanobu Kobayashi, Kazuaki Ohara, Takayuki Ohshima, Hiroshi Miyazawa   +8 more
doaj   +1 more source

A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ

Life Science Alliance, 2021
As an integral scaffolding component of DNA polymerase (Pol) zeta, Pol lambda adapts Pol zeta–dependent translesion synthesis to operate in a predominantly error-free manner in human cells.
Jung-Hoon Yoon, Debashree Basu, Karthi Sellamuthu, Robert E Johnson, Satya Prakash, Louise Prakash   +5 more
doaj   +1 more source

Promutagenicity of 8-Chloroguanine, A Major Inflammation-Induced Halogenated DNA Lesion

Molecules, 2019
Chronic inflammation is closely associated with cancer development. One possible mechanism for inflammation-induced carcinogenesis is DNA damage caused by reactive halogen species, such as hypochlorous acid, which is released by myeloperoxidase to kill ...
Yi Kou, Myong-Chul Koag, Seongmin Lee
doaj   +1 more source

Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions [PDF]

, 2010
Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions.
Sonoda, E, Dávid Szüts, Hirota Kouji, Takuo Kawamoto, Shunichi Takeda, Motegi, Akira, Motegi Akira, Fumio Hanaoka, Kawamoto Takuo, Julian E. Sale, Kawamoto, Takuo, Iwai, Shigenori, Julian E Sale, Sale Julian E., Sonoda Eiichiro, Masutani Chikahide, Shigenori Iwai, Alan Lehmann, Masutani, C, Takeda, Shunichi, Iwai Shigenori, Lehmann, Alan, Chikahide Masutani, Szüts, Dávid, Iwai, S, Eiichiro Sonoda, Motegi, A, Kawamoto, T, Masutani, Chikahide, Kouji Hirota, Hanaoka Fumio, Szüts, D, Takeda Shunichi, Hirota, Kouji, Sale, Julian E, Szüts Dávid, Hanaoka, Fumio, Lehmann Alan, Takeda, S, Hirota, K, Hanaoka, F, Sale, JE, Akira Motegi, Sonoda, Eiichiro, Lehmann, A   +44 more
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DNA Polymerase e - More Than a Polymerase

The Scientific World Journal, 2003
This paper presents a comprehensive review of the structure and function of DNA polymerase e. Together with DNA polymerases a and d, this enzyme replicates the nuclear DNA in the eukaryotic cell.
Helmut Pospiech, Juhani E. Syväoja
doaj   +1 more source