Results 221 to 230 of about 3,282,036 (289)

Deciphering the structural consequences of R83 and R152 methylation on DNA polymerase β using molecular modeling. [PDF]

PLoS One
Srivastava A, Idriss H, Das G, Abedrabbo S, Shamsir MS, Homouz D.   +5 more
europepmc   +1 more source

Transcriptome‐Wide Association Uncovers LncRNAs Controlling Seed Weight in Soybean

Advanced Science, EarlyView.
This study employs transcriptome‐wide association studies (TWAS) to identify 201 long non‐coding RNAs (lncRNAs) associated with seed weight. Expression quantitative trait locus (eQTL) analysis reveals dynamic and static regulatory variants controlling lncRNA expression across development.
Xiang Wang, Xinyu Jiang, Xiaobo Yuan, Zhipeng Zhou, Zhenwei Zhao, Longfei Wang, Wu Jiao, Wenxue Ye, Qingxin Song   +8 more
wiley   +1 more source

A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens

Smits WK, Urem M, Friggen A, Musch N, Silverman M, Swain C, Barbachyn M, Mortin L, Yu X, DeLuccia R, Lamers M.   +10 more
europepmc   +1 more source

Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity. [PDF]

Biochemistry
Thomas C, Avalos-Irving L, Victorino J, Green S, Andrews M, Rodrigues N, Ebirim S, Mudd A, Towle-Weicksel JB.   +8 more
europepmc   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum

Kumari A, Enache T, Craggs TD, Pata JD, Lahiri I.   +4 more
europepmc   +1 more source

ADH5/ALDH2 dehydrogenases and DNA polymerase theta protect normal and malignant hematopoietic cells from formaldehyde challenge: therapeutic implications. [PDF]

Leukemia
Atkins J, Kukuyan AM, Toma M, Drzewiecka M, Vekariya U, Karami A, Nieborowska-Skorska M, Nejati R, Hadzijusufovic E, Valent P, Stoklosa T, Sliwinski T, Wasik M, Skorski T.   +13 more
europepmc   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Cryo-EM Structures of the Plasmodium falciparum Apicoplast DNA Polymerase. [PDF]

J Mol Biol
Lo CY, Ung AR, Koley T, Nelson SW, Gao Y.   +4 more
europepmc   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source