Results 241 to 250 of about 898,091 (296)
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo+10 more
wiley +1 more source
Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA. [PDF]
Shin Y, Hedglin M, Murakami KS.
europepmc +1 more source
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang+5 more
wiley +1 more source
Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV-1 DNA Polymerase Inhibitors. [PDF]
Wei L+15 more
europepmc +1 more source
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang+10 more
wiley +1 more source
Mapping fast DNA polymerase exchange during replication. [PDF]
Xu L, Halma MTJ, Wuite GJL.
europepmc +1 more source
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu+4 more
wiley +1 more source
DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion. [PDF]
Das M+9 more
europepmc +1 more source
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang+11 more
wiley +1 more source
The mutational landscape of Bacillus subtilis conditional hypermutators shows how proofreading skews DNA polymerase error rates. [PDF]
Tanneur I+5 more
europepmc +1 more source