Results 51 to 60 of about 1,030,716 (269)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion

eLife, 2016
Translesion DNA synthesis (TLS) during S-phase uses specialized TLS DNA polymerases to replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending damage.
Mark Hedglin, Binod Pandey, Stephen J Benkovic   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Utility of the Bacteriophage RB69 Polymerase gp43 as a Surrogate Enzyme for Herpesvirus Orthologs

Viruses, 2013
Viral polymerases are important targets in drug discovery and development efforts. Most antiviral compounds that are currently approved for treatment of infection with members of the herpesviridae family were shown to inhibit the viral DNA polymerase ...
Nicholas Bennett, Matthias Götte
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae

, 2007
Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative clamp protein, PCNA.
Bielen, Aleksandra B., Ulrich, Helle D., Parker, Joanne L., Đikić, Ivan   +3 more
core   +1 more source

A Conserved GA Element in TATA-Less RNA Polymerase II Promoters [PDF]

, 2011
Initiation of RNA polymerase (Pol) II transcription requires assembly of the pre-initiation complex (PIC) at the promoter. In the classical view, PIC assembly starts with binding of the TATA box-binding protein (TBP) to the TATA box.
Hartmann, H., Kurth, F., Cramer, P., Hartmann, Holger, Hartmann Holger, Martin Dietmar E., Söding Johannes, Seizl, Martin, Kurth Fabian, Martin, D., Martin Seizl, Fabian Kurth, Cramer Patrick, Hoeg Friederike, Söding* Patrick Cramer, Martin, Dietmar E., Hoeg, F., Cramer, Patrick, Patrick Cramer, Soeding, J., Johannes Söding, Holger Hartmann, Hoeg, Frederike, Kurth, Fabian, Söding, J., Seizl, M., Seizl Martin, Söding, Johannes, Dietmar E Martin, Friederike Hoeg, Martin, D. E., Hoeg, Friederike, Dietmar E. Martin   +32 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle. [PDF]

, 2011
RNA polymerase I (Pol I) produces large ribosomal RNAs (rRNAs). In this study, we show that the Rpa49 and Rpa34 Pol I subunits, which do not have counterparts in Pol II and Pol III complexes, are functionally conserved using heterospecific ...
Gadal, O., Leger-Silvestre, Isabelle, Ostermaier, M.K., Panov, Konstantin; id_orcid, Panov, Kostya I, Schultz, P., Leger-Silvestre, I. (I), Olivier Gadal, Jorge Pérez-Fernández, Albert, Benjamin, Leger-Silvestre, I., Ostermaier, Martin K, Kostya I. Panov, Perez-Fernandez, J., Normand, C. (C), Schultz, Patrick, Schultz, P. (Patrick), Panov, Kostya I., Patrick Schultz, Gadal, O. (O), Normand, Christophe, Martin K. Ostermaier, Normand, C., Zomerdijk, Joost C.B.M., Albert, B. (B), Perez-Fernandez, J. (J), Ostermaier, M. (M) K. (K), Ostermaier, Martin K., Christophe Normand, Zomerdijk, Joost C B M, Gadal, Olivier, Joost C.B.M. Zomerdijk, Zomerdijk, J.C., Perez-Fernandez, Jorge, Isabelle Léger-Silvestre, Albert, B., Panov, K. (K) I. (I), Zomerdijk, Joost C. B. M., Benjamin Albert, Zomerdijk, J. (J) C. (C)   +39 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source