Understanding Active Photoprotection: DNA-Repair Enzymes and Antioxidants [PDF]
LifeThe detrimental effects of ultraviolet radiation (UVR) on human skin are well-documented, encompassing DNA damage, oxidative stress, and an increased risk of carcinogenesis.
Emilio Garcia-Mouronte +3 more
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DNA repair enzymes in sunscreens and their impact on photoageing-A systematic review. [PDF]
Photodermatol Photoimmunol Photomed, 2020 DNA damage is one of the main factors responsible for photoageing and is predominantly attributed to ultraviolet irradiation (UV‐R). Photoprotection by conventional sunscreens is exclusively prophylactic, and of no value, once DNA damage has occurred. As
Luze H +4 more
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Annual Review of Biochemistry, 1982 The invention relates to methods of selection of agents and compositions for the treatment of proliferative diseases such as cancer. More specifically, the present invention relates to the methods of selecting compounds which modulate the activity of DNA repair enzymes HAB1 and HAB2 and their uses in the treatment of disorders, which would benefit from
T. Lindahl
semanticscholar +3 more sources
Rolling circle amplification-driven encoding of different fluorescent molecules for simultaneous detection of multiple DNA repair enzymes at the single-molecule level. [PDF]
Chem Sci, 2020 Integration of single-molecule detection with rolling circle amplification-driven encoding of different fluorescent molecules enables simultaneous detection of multiple DNA repair enzymes.
Li CC, Chen HY, Hu J, Zhang CY.
europepmc +2 more sources
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro. [PDF]
Nucleic Acids Res, 2019 5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET ...
Bian K +9 more
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Folding-upon-Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes. [PDF]
Angew Chem Int Ed Engl, 2021 AbstractWe present a new class of DNA‐based nanoswitches that, upon enzymatic repair, could undergo a conformational change mechanism leading to a change in fluorescent signal. Such folding‐upon‐repair DNA nanoswitches are synthetic DNA sequences containing O6‐methyl‐guanine (O6‐MeG) nucleobases and labelled with a fluorophore/quencher optical pair ...
Farag N +7 more
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Comet assay to measure DNA repair: approach and applications. [PDF]
Frontiers in Genetics, 2014 Cellular repair enzymes remove virtually all DNA damage before it is fixed; repair therefore plays a crucial role in preventing cancer. Repair studied at the level of transcription correlates poorly with enzyme activity, and so assays of phenotype are ...
Amaya eAzqueta +4 more
doaj +3 more sources
DNA repair enzymes of the Antarctic Dry Valley metagenome [PDF]
Frontiers in Microbiology, 2023 Microbiota inhabiting the Dry Valleys of Antarctica are subjected to multiple stressors that can damage deoxyribonucleic acid (DNA) such as desiccation, high ultraviolet light (UV) and multiple freeze-thaw cycles.
Elizabeth Rzoska-Smith +4 more
doaj +2 more sources
DNA damage by peroxynitrite characterized with DNA repair enzymes. [PDF]
Nucleic Acids Research, 1996 The DNA damage induced by peroxynitrite in isolated bacteriophage PM2 DNA was characterized by means of several repair enzymes with defined substrate specificities. Similar results were obtained with peroxynitrite itself and with 3-morpholinosydnonimine (SIN-1), a compound generating the precursors of peroxynitrite, nitric oxide and superoxide.
B. Epe +4 more
semanticscholar +3 more sources
DNA-protein crosslink repair: proteases as DNA repair enzymes.
Trends in Biochemical Sciences, 2015 DNA-protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with DNA transactions. The recent discovery of a yeast protease that processes DPCs proteolytically raises the question whether DPC proteases also exist in higher eukaryotes.
Julian Stingele +2 more
semanticscholar +5 more sources