Endogenous DNA Damage and Repair Enzymes
Genomics, Proteomics & Bioinformatics, 2016 Tomas Lindahl completed his medical studies at Karolinska Institute in 1970. Yet, his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA repair.
Arne Klungland, Yun-Gui Yang
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Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides [PDF]
Nature CommunicationsPhosphorothioate (PS)-modified antisense oligonucleotides (ASOs) are widely used to modulate gene expression in basic research and therapy. Within cells, these ASOs seed nuclear structures with unclear functions and consequences.
Linn Hjelmgren +9 more
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The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2 [PDF]
Вавиловский журнал генетики и селекцииOncological diseases remain a leading cause of pathological mortality worldwide, making the development of anticancer drugs a critical focus in medicinal chemistry.
N. S. Dyrkheeva +10 more
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Six critical questions for DNA repair enzymes in skincare products: a review in dialog [PDF]
Clinical, Cosmetic and Investigational Dermatology, 2019 Daniel B Yarosh,1 Amanda Rosenthal,2,3 Ronald Moy31Daniel B Yarosh Inc., Merrick, NY, USA; 2Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA; 3Research Department, Moy-Fincher-Chipps Facial Plastics/Dermatology ...
Yarosh DB, Rosenthal A, Moy R
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Copper Inhibits the AlkB Family DNA Repair Enzymes under Wilson's Disease Condition. [PDF]
Chem Res Toxicol, 2017 Bian K +4 more
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Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. [PDF]
Chem Res Toxicol, 2017 Chen F +7 more
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Natural Sun-Screening Compounds and DNA-Repair Enzymes: Photoprotection and Photoaging
Catalysts, 2023 Ultraviolet radiation (UVR) has been scientifically proven to cause skin disorders such as sunburn, skin cancer and the symptoms of chronic exposure.
Amit Gupta +8 more
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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
eLife, 2021 BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage ...
Xiangrong Chen +13 more
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mBio, 2021 Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers.
Apurva T. Prabhakar +16 more
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The Domino Effect: Nucleosome Dynamics and the Regulation of Base Excision Repair Enzymes
DNA, 2022 DNA damage is induced by exogenous and endogenous sources, creating a variety of lesions. However, the cellular repair machinery that addresses and corrects this damage must contend with the fact that genomic DNA is sequestered in the nucleoprotein ...
Julia C. Cook, Sarah Delaney
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