Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]
, 2015 Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty +17 more
core +1 more source
Charge-transport-mediated recruitment of DNA repair enzymes [PDF]
The Journal of Chemical Physics, 2008 Damaged or mismatched bases in DNA can be repaired by base excision repair enzymes (BER) that replace the defective base. Although the detailed molecular structures of many BER enzymes are known, how they colocalize to lesions remains unclear. One hypothesis involves charge transport (CT) along DNA [Yavin et al., Proc. Natl. Acad. Sci. U.S.A. 102, 3546
Fok, Pak-Wing, Guo, Chin-Lin, Chou, Tom
openaire +4 more sources
An End to a Means: How DNA-End Structure Shapes the Double-Strand Break Repair Process [PDF]
, 2020 Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5'-phosphate, 3'-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair.
Cortés Ledesma, Felipe +2 more
core +1 more source
Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
doaj +1 more source
Cell Reports, 2015 Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients.
Pu Wang +10 more
semanticscholar +1 more source
Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme—The spore photoproduct lyase [PDF]
, 2017 DNA repair enzymes typically recognize their substrate lesions with high affinity to ensure efficient lesion repair. In UV irradiated endospores, a special thymine dimer, 5-thyminyl-5,6-dihydrothymine, termed the spore photoproduct (SP), is the dominant ...
Jian, Yajun +3 more
core +1 more source
PLoS ONE, 2011 Host DNA repair enzymes have long been assumed to play a role in HIV replication, and many different DNA repair factors have been associated with HIV.
Amy S Espeseth +6 more
doaj +1 more source
Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium [PDF]
, 2007 BACKGROUND: Enzymes involved in DNA metabolic events of the highly radioresistant bacterium Deinococcus radiodurans are currently examined to understand the mechanisms that protect and repair the Deinococcus radiodurans genome after extremely high doses ...
Blasius, M +3 more
core +3 more sources
Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer
Scientific Reports, 2022 DNA damaging agents are a mainstay of standard chemotherapy for ovarian cancer. Unfortunately, resistance to such DNA damaging agents frequently develops, often due to increased activity of DNA repair pathways.
Lia Tesfay +9 more
doaj +1 more source
Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]
, 2016 Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya +7 more
core +1 more source