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Enzyme Structures: DNA repair flips out [PDF]
Current Biology, 1995 New insights into the workings of the repair enzymes that police the genome for damage to DNA come from the recently determined structures of two uracil-DNA glycosylases.
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ATM in focus:a damage sensor and cancer target [PDF]
, 2012 The ability of a cell to conserve and maintain its native DNA sequence is fundamental for the survival and normal functioning of the whole organism and protection from cancer development.
Khalil, Hilal S. +2 more
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PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
Nature Communications, 2016 Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy +12 more
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A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions
Cell Reports, 2014 Summary: DNA repair scaffolds mediate specific DNA and protein interactions in order to assist repair enzymes in recognizing and removing damaged sequences. Many scaffold proteins are dedicated to repairing a particular type of lesion. Here, we show that
Prabha Sarangi +9 more
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DNA double strand break repair enzymes function at multiple steps in retroviral infection [PDF]
, 2009 (c) 2009 Sakurai et al; licensee BioMed Central Ltd. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Sakurai Yasuteru +3 more
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Targeting the DNA damage response and repair in cancer through nucleotide metabolism
Molecular Oncology, 2022 The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which are ...
Thomas Helleday, Sean G. Rudd
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dUTPase based switch controls transfer of virulence genes in order to preserve integrity of the transferred mobile genetic elements [PDF]
, 2013 dUTPases ubiquitously regulate cellular dUTP levels to preserve genome integrity. Recently, several other cellular processes were reported to be controlled by dUTPases including the horizontal transfer of Staphylococcus aureus pathogenicity islands ...
Bendes, A. +12 more
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Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
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Medycyna Pracy, 2018 Genetic polymorphism is associated with the occurrence of at least 2 different alleles in the locus with a frequency higher than 1% in the population.
Karol Bukowski, Katarzyna Woźniak
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DNA-repair enzyme turns to translation
Nature, 2020 A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes — the molecular machines that translate the genetic code into protein.
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