Results 201 to 210 of about 2,635,192 (296)

Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. [PDF]

Nucleic Acids Res, 2023
Liu K, Xiao Y, Gan L, Li W, Zhang J, Min J.   +5 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

In silico development of HASDI-G2 as a novel agent for selective recognition of the DNA sequence. [PDF]

Sci Rep
Zaremba A, Zaremba P, Zahorodnia S.
europepmc   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding. [PDF]

Oncogene
Tian L, Jiao X, Wang C, Li D, Ertel A, Achinger-Kawecka J, Addya S, Soccio RE, Chen ER, Győrffy B, Di Sante G, Zhong Z, Alkhafaji H, Entcheva N, Campbell EM, McCue PA, Kossenkov AV, Pancsa R, Tompa P, Clark SJ, Pestell RG.   +20 more
europepmc   +1 more source

In Search of Glacial Refuges of the Land Snail Orcula dolium (Pulmonata, Orculidae) - An Integrative Approach Using DNA Sequence and Fossil Data

, 2014
Harl, Josef, Duda, Michael, Kruckenhauser, Luise, Sattmann Helmut, Haring Elisabeth   +4 more
openalex   +2 more sources

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation. [PDF]

Nat Genet
Linder J, Srivastava D, Yuan H, Agarwal V, Kelley DR.   +4 more
europepmc   +1 more source

Systematic investigation of sequence requirements for DNA i-motif formation [PDF]

, 2019
Školáková, Petra, Renčiuk, Daniel, Palacký, Jan, Krafcik, Daniel, Dvořáková, Zuzana, Kejnovská, Iva, Bednářová, Klára, Vorlíčková, Michaela   +7 more
openalex   +1 more source

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source