Results 101 to 110 of about 3,728,691 (365)

Nanopore-based technologies beyond DNA sequencing

Nature Nanotechnology, 2022
Yilun Ying, Zheng-Li Hu, Shengli Zhang, Yujia Qing, A. Fragasso, G. Maglia, A. Meller, H. Bayley, C. Dekker, Yitao Long   +9 more
semanticscholar   +1 more source

A DNA barcoding framework for taxonomic verification in the Darwin Tree of Life Project

Wellcome Open Research
Biodiversity genomics research requires reliable organismal identification, which can be difficult based on morphology alone. DNA-based identification using DNA barcoding can provide confirmation of species identity and resolve taxonomic issues but is ...
A. Twyford, Jordan Beasley, Ian Barnes, Heather Allen, Freja Azzopardi, D. Bell, Mark L. Blaxter, Gavin R. Broad, Lucía Campos-Domínguez, Darren Choonea, Liam M. Crowley, Piotr Cuber, Michael Cunliffe, Alexandra Dombrowski, Brian Douglas, L. Forrest, Ester Gaya, Clementine Greeves, Claire Griffin, Joanna Harley, Michelle L Hart, Peter W. H. Holland, Peter M. Hollingsworth, Inez Januszczak, Amanda Jones, Paul J. Kersey, Estelle Kilias, M. Lawniczak, Owen T. Lewis, Sahr Mian, Alice Minotto, Raju Misra, Peter O. Mulhair, Lyndall Pereira da Conceicoa, Benjamin W. Price, Silvia Salatino, Felix Shaw, Olga Sivell, Laura Sivess, Rebekka Uhl, Kieran Woof   +40 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Medical DNA sequencing [PDF]

Current Opinion in Cardiology, 2011
To discuss implications of information garnered through whole-genome and exome sequencing in the practice of cardiovascular medicine.Whole-genome and exome sequencing unveils medical information embedded in individual genomes and exomes, which could be incorporated into the practice of medicine for diagnostic and therapeutic gains.
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

A strategy of DNA sequencing employing computer programs [PDF]

, 1979
Rodger Staden
openalex   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

The use of exonuclease III for preparing single stranded DNA for use as a template in the chain terminator sequencing method [PDF]

, 1979
Andrew J.H. Smith
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Reduced plastid genomes of colorless facultative pathogens Prototheca (Chlorophyta) are retained for membrane transport genes

BMC Biology
Background Plastids are usually involved in photosynthesis, but the secondary loss of this function is a widespread phenomenon in various lineages of algae and plants.
Kacper Maciszewski, Gabriela Wilga, Tomasz Jagielski, Zofia Bakuła, Jan Gawor, Robert Gromadka, Anna Karnkowska   +6 more
doaj   +1 more source