Results 231 to 240 of about 3,677,492 (346)

Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort. [PDF]

Acta Neuropathol Commun
Fischer TT, Maaß KK, Puranachot P, Mieskolainen M, Sill M, Schad PS, Volz S, Rosing F, Wedig T, Schwarz N, Finster AME, Iser F, Meyer J, Sahm F, Lohi O, Damaty AE, Brors B, Haapasalo H, Pfister SM, Haapasalo J, Pajtler KW, Nordfors K.   +21 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

GenoPath: a pipeline to infer tumor clone composition, mutational history, and metastatic cell migration events from tumor DNA sequencing data. [PDF]

Front Bioinform
Tobin RM, Singh S, Kumar S, Miura S.
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Plasma Microbial Cell-free DNA Sequencing for the Detection of Kingella kingae Pediatric Spinal Infections. [PDF]

Pediatr Infect Dis J
Ahmed AA, Park SY, Smollin MJ, Lindner MS, Sarmiento Clemente A, Del Valle Penella A, Laufer PM, Sanchez-Vegas C, Cotilla MR, Melish ME, Trieu C, Kabani NA, Cooper J, Lloyd AR, Kimberlin DW, Arnold JC, Jordan-Villegas A, Patterson LE, Foster CE, Yagupsky P.   +19 more
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution. [PDF]

Cell Genom
Poon G, Vedi A, Sanders M, Laurenti E, Valk P, Blundell JR.   +5 more
europepmc   +1 more source

Isolation and sequencing of cDNAs and genomic DNAs encoding the alpha 4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2.

, 1992
Y Kamagata, Marie‐Geneviève Mattéi, Y Ninomiya   +2 more
openalex   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Fast and efficient method for parallel construction of targeted exome and methylome single-stranded DNA sequencing libraries. [PDF]

Sci Rep
Kim E, An S, Ahn H, Lim J, Kim SK, Park AK.   +5 more
europepmc   +1 more source