Results 191 to 200 of about 17,272 (247)

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Do the Shuffle: Expanding the Synthetic Biology Toolkit for Shufflon-like Recombination Systems. [PDF]

ACS Synth Biol
Katalinić J, Richards M, Auyang A, Millett JH, Kogenaru M, Windbichler N.   +5 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Exogenous diatoms ameliorate thermal bleaching of symbiont bearing benthic foraminifera. [PDF]

Proc Biol Sci
Titelboim D, Dedman CJ, Hodgson RP, Knowles LS, Liu X, Lenzi L, Tudor J, Vamos E, Rickaby REM.   +8 more
europepmc   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

A generative adversarial network for multiple reads reconstruction in DNA storage. [PDF]

Sci Rep
Zheng X, Xie R, Yao X, Su Y, Chu L, Xu P, Liu W.   +6 more
europepmc   +1 more source

Population-wide single-pollen nuclei genotyping in rye sheds light on the genetic basis and environmental plasticity of meiotic recombination. [PDF]

New Phytol
Waesch C, Gaede N, Gao Y, Ehle M, Himmelbach A, Fuchs J, Johnston SE, Dreissig S.   +7 more
europepmc   +1 more source

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions. [PDF]

Nat Cell Biol
Langstein-Skora I, Schmid A, Huth F, Shabani D, Spechtenhauser L, Likhodeeva M, Kunert F, Metzner FJ, Emenecker RJ, Richardson MO, Aftab W, Götz MJ, Payer SK, Pietrantoni N, Valka V, Ravichandran SK, Bartke T, Hopfner KP, Gerland U, Korber P, Holehouse AS.   +20 more
europepmc   +1 more source

Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation. [PDF]

Curr Opin Genet Dev
Rosspopoff O, Trono D, Feschotte C.
europepmc   +1 more source