Results 61 to 70 of about 12,600 (157)

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, Volume 13, Issue 2, 9 January 2026.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy

Bioengineering, 2019
There is an increased interest in plasmid DNA as therapeutics. This is evident in the number of ongoing clinical trials involving the use of plasmid DNA.
Olusegun Folarin, Darren Nesbeth, John M. Ward, Eli Keshavarz-Moore   +3 more
doaj   +1 more source

Structural Coupling between RNA Polymerase Composition and DNA Supercoiling in Coordinating Transcription: a Global Role for the Omega Subunit?

mBio, 2011
In growing bacterial cells, the global reorganization of transcription is associated with alterations of RNA polymerase composition and the superhelical density of the DNA.
Marcel Geertz, Andrew Travers, Sanja Mehandziska, Patrick Sobetzko, Sarath Chandra Janga, Nobuo Shimamoto, Georgi Muskhelishvili   +6 more
doaj   +1 more source

Specific anchoring of large topologically closed DNA for single-molecule protein:DNA interactions

Biophysical Reports
Single-molecule and bulk biophysical approaches to study protein-DNA interactions on surface-immobilized nucleic acid templates typically rely on modifying the ends of linear DNA molecules to enable surface-DNA attachments.
Neville S. Gilhooly, Stephen C. Kowalczykowski   +1 more
doaj   +1 more source

Gyrase containing a single C-terminal domain catalyzes negative supercoiling of DNA by decreasing the linking number in steps of two [PDF]

, 2018
Jampa Tsedön Stelljes, Daniela Weidlich, Airat Gubaev, Dagmar Klostermeier   +3 more
openalex   +1 more source

Rates of gyrase supercoiling and transcription elongation control supercoil density in a bacterial chromosome.

PLoS Genetics, 2012
Gyrase catalyzes negative supercoiling of DNA in an ATP-dependent reaction that helps condense bacterial chromosomes into a compact interwound "nucleoid." The supercoil density (σ) of prokaryotic DNA occurs in two forms. Diffusible supercoil density (σ(D)
Nikolay Rovinskiy, Andrews Akwasi Agbleke, Olga Chesnokova, Zhenhua Pang, N Patrick Higgins   +4 more
doaj   +1 more source

The Handedness of Nucleosomes is Governed by the Supercoiling of DNA [PDF]

, 2016
Sung Hyun Kim, Rifka Vlijm, Paul de Zwart, Jaco van der Torre, Yamini Dalal, Cees Dekker   +5 more
openalex   +1 more source

Topological diversity of chromatin fibers: Interplay between nucleosome repeat length, DNA linking number and the level of transcription

AIMS Biophysics, 2015
The spatial organization of nucleosomes in 30-nm fibers remains unknown in detail. To tackle this problem, we analyzed all stereochemically possible configurations of two-start chromatin fibers with DNA linkers L = 10-70 bp (nucleosome repeat length NRL =
Davood Norouzi, Ataur Katebi, Feng Cui, Victor B. Zhurkin   +3 more
doaj   +1 more source

ATP-Dependent Positive Supercoiling of DNA by 13S Condensin: A Biochemical Implication for Chromosome Condensation [PDF]

, 1997
Keiji Kimura, Tatsuya Hirano
openalex   +1 more source

SupercoiledDNA: Structure [PDF]

, 2015
Richard P. Bowater
openalex   +1 more source