Results 51 to 60 of about 2,295,017 (227)
Behavior of Supercoiled DNA [PDF]
Biophysical Journal, 1998 We study DNA supercoiling in a quantitative fashion by micromanipulating single linear DNA molecules with a magnetic field gradient. By anchoring one end of the DNA to multiple sites on a magnetic bead and the other end to multiple sites on a glass surface, we were able to exert torsional control on the DNA. A rotating magnetic field was used to induce
Strick, T.R. +3 more
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The effects of DNA supercoiling on G-quadruplex formation. [PDF]
Nucleic Acids Res, 2017 Guanine-rich DNAs can fold into four-stranded structures that contain stacks of G-quartets. Bioinformatics studies have revealed that G-rich sequences with the potential to adopt these structures are unevenly distributed throughout genomes, and are ...
Sekibo DAT, Fox KR.
europepmc +2 more sources
Effects of DNA supercoiling on chromatin architecture
Biophysical Reviews, 2016 Disruptions in chromatin structure are necessary for the regulation of eukaryotic genomes, from remodelling of nucleosomes at the base pair level through to large-scale chromatin domains that are hundreds of kilobases in size.
S. Corless, N. Gilbert
semanticscholar +2 more sources
Interaction of the Escherichia coli HU Protein with Various Topological Forms of DNA
Biomolecules, 2021 E. coli histone-like protein HU has been shown to interact with different topological forms of DNA. Using radiolabeled HU, we examine the effects of DNA supercoiling on HU–DNA interactions.
Li Huang, Zhenfeng Zhang, Roger McMacken
doaj +1 more source
Energy required to pinch a DNA plectoneme [PDF]
, 2018 DNA supercoiling plays an important role on a biological point of view. One of its consequences at the supra-molecular level is the formation of DNA superhelices named plectonemes.
Barde, Céline +2 more
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Dimensions of plectonemically supercoiled DNA [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2002 With a view to determine the configuration and regularity of plectonemically supercoiled DNA, we have measured the small angle neutron scattering from pUC18 plasmid in saline solutions. Furthermore, we have derived the mathematical expression for the single chain scattering function (form factor) of a superhelical structure, including the longitudinal ...
Zakharova, Svetlana S. +5 more
openaire +3 more sources
Supercoiling Effects on Short-Range DNA Looping in E. coli. [PDF]
PLoS ONE, 2016 DNA-protein loops can be essential for gene regulation. The Escherichia coli lactose (lac) operon is controlled by DNA-protein loops that have been studied for decades.
Lauren S Mogil +2 more
doaj +1 more source
Data in Brief, 2020 In enteric bacteria, DNA supercoiling is highly responsive to environmental conditions. Host specific features of environment serve as cues for the expression of genes required for colonization of host niches via changing supercoiling [1].
Natalia E. Gogoleva +4 more
doaj +1 more source
A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase [PDF]
, 2009 Simocyclinones are bifunctional antibiotics that inhibit bacterial DNA gyrase by preventing DNA binding to the enzyme. We report the crystal structure of the complex formed between the N-terminal domain of the Escherichia coli gyrase A subunit and ...
A. Maxwell +29 more
core +1 more source
Journal of Cell Science, 1975 ABSTRACT The three-dimensional structure of a double-stranded DNA molecule may be described by distinguishing the helical turns of the DNA duplex from any superhelical turns that might be superimposed upon the duplex turns. There are characteristic changes in the hydrodynamic properties of superhelical DNA molecules when they interact ...
Cook, P, Brazell, I
openaire +3 more sources