Results 41 to 50 of about 2,295,017 (227)
Getting DNA twist rigidity from single molecule experiments [PDF]
, 2004 We use an elastic rod model with contact to study the extension versus rotation diagrams of single supercoiled DNA molecules. We reproduce quantitatively the supercoiling response of overtwisted DNA and, using experimental data, we get an estimation of ...
A. V. Vologodskii +10 more
core +3 more sources
A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2. [PDF]
PLoS Genetics, 2012 DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein-DNA and protein-protein interactions is poorly understood.
Andrew D S Cameron, Charles J Dorman
doaj +1 more source
DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? [PDF]
Int J Mol Sci, 2018 Although our knowledge of chromatin organization has advanced significantly in recent years, much about the relationships between different features of genome architecture is still unknown.
Björkegren C, Baranello L.
europepmc +2 more sources
mSystems, 2021 Bacterial gene expression is controlled at multiple levels, with chromosome supercoiling being one of the most global regulators. Global DNA supercoiling is maintained by the orchestrated action of topoisomerases.
Martyna Gongerowska-Jac +8 more
doaj +1 more source
Counterintuitive DNA Sequence Dependence in Supercoiling-Induced DNA Melting.
PLoS ONE, 2015 The metabolism of DNA in cells relies on the balance between hybridized double-stranded DNA (dsDNA) and local de-hybridized regions of ssDNA that provide access to binding proteins.
Rifka Vlijm, Jaco V D Torre, Cees Dekker
doaj +1 more source
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures [PDF]
, 2013 DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharacterized.
A Saunders +61 more
core +2 more sources
Profiling DNA supercoiling domains in vivo
Genomics Data, 2014 Transitions in DNA structure have the capacity to regulate genes, but have been poorly characterised in eukaryotes due to a lack of appropriate techniques.
Samuel Corless +2 more
doaj +1 more source
Effects of DNA Topology on Transcription from rRNA Promoters in Bacillus subtilis
Microorganisms, 2021 The expression of rRNA is one of the most energetically demanding cellular processes and, as such, it must be stringently controlled. Here, we report that DNA topology, i.e., the level of DNA supercoiling, plays a role in the regulation of Bacillus ...
Petra Sudzinová +5 more
doaj +1 more source
Frontiers in Microbiology, 2019 Negative DNA supercoiling allows chromosome condensation and facilitates DNA unwinding, which is required for the occurrence of DNA transaction processes, i.e., DNA replication, transcription and recombination.
Marcin Jan Szafran +4 more
doaj +1 more source
Inhibition of the gyrA promoter by transcription-coupled DNA supercoiling in Escherichia coli. [PDF]
Sci Rep, 2018 The E. coli gyrA promoter (PgyrA) is a DNA supercoiling sensitive promoter, stimulated by relaxation of DNA templates, and inhibited by (−) DNA supercoiling in bacteria.
Dages S, Dages K, Zhi X, Leng F.
europepmc +2 more sources