Results 41 to 50 of about 1,452,122 (130)

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Stochastic Entanglement of Deterministic Origami Tentacles For Robust Robotic Grasping

Advanced Science, EarlyView.
This study introduces an origami tentacle gripper to robustly grasp objects‐in air, underwater, and even in orbital space‐by exploiting a synergy between local, deterministic deformation programming and global, stochastic entanglements. A single origami tentacle can be designed to coil with a simple tendon pull.
Alec Boron, Bokun Zheng, Ziyang Zhou, Noel Naughton, Suyi Li   +4 more
wiley   +1 more source

The interplay between supercoiling and DNA modifying enzymes at the single-molecule level

Scientific Reports
DNA supercoiling refers to the overwinding or underwinding of the double helix, forming plait-like structures called plectonemes. Supercoiling is involved in all biological processes that occur on DNA.
Elise M. Wilkinson, Antoine M. van Oijen, Timothy D. Craggs, Stefan H. Mueller, Lisanne M. Spenkelink   +4 more
doaj   +1 more source

An improved method for large-scale preparation of negatively and positively supercoiled plasmid DNA

BioTechniques, 2009
A rigorous understanding of the biological function of superhelical tension in cellular DNA requires the development of new tools and model systems for study.
Marita C. Barth, Debra A. Dederich, Peter C. Dedon   +2 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

DNA supercoiling-induced shapes alter minicircle hydrodynamic properties [PDF]

, 2023
DNA in cells is organized in negatively supercoiled loops. The resulting torsional and bending strain allows DNA to adopt a surprisingly wide variety of 3-D shapes.
Catanese, Daniel J, Jr., Zechiedrich, Lynn, Fogg, Jonathan M, Ekiel-Jeżewska, Maria L, Waszkiewicz, Radost, Demeler, Borries, Szymczak, Piotr, Ranasinghe, Maduni, Lisicki, Maciej   +8 more
core   +1 more source

Emergence of supercoiling-mediated regulatory networks through the evolution of bacterial chromosome organization.

PLoS Computational Biology
DNA supercoiling-the level of twisting and writhing of the DNA molecule around itself-plays an important role in the regulation of gene expression in bacteria by modulating promoter activity.
Théotime Grohens, Sam Meyer, Guillaume Beslon   +2 more
doaj   +1 more source

Genome scale patterns of supercoiling in a bacterial chromosome

Nature Communications, 2016
Bacterial DNA primarily exists in a negatively supercoiled or under-wound state. Here, by mapping the supercoiling state, the authors show that there is a gradient of supercoiling across the bacterial chromosome with the terminus being more negatively ...
Avantika Lal, Amlanjyoti Dhar, Andrei Trostel, Fedor Kouzine, Aswin S. N. Seshasayee, Sankar Adhya   +5 more
doaj   +1 more source

Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins. [PDF]

PLoS ONE, 2018
It is well accepted that the introduction of negative supercoils locally unwinds the DNA double helix, influencing thus the activity of proteins. Despite the use of recent methods of molecular dynamics simulations to model the DNA supercoiling-induced ...
Carole Saintomé, Emmanuelle Delagoutte
doaj   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source