Results 21 to 30 of about 2,295,017 (227)
Frontiers in Cellular and Infection Microbiology, 2012 The prevalence of fluoroquinolone (FQ)-resistant Campylobacter has become a concern for public health. To facilitate the control of FQ-resistant Campylobacter, it is necessary to understand the impact of FQ resistance on the fitness of Campylobacter in ...
Jing eHan +7 more
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The regulation of DNA supercoiling across evolution. [PDF]
Protein Sci, 2021 DNA supercoiling controls a variety of cellular processes, including transcription, recombination, chromosome replication, and segregation, across all domains of life.
Duprey A, Groisman EA.
europepmc +2 more sources
DNA supercoiling-mediated collective behavior of co-transcribing RNA polymerases. [PDF]
Nucleic Acids Res, 2022 Multiple RNA polymerases (RNAPs) transcribing a gene have been known to exhibit collective group behavior, causing the transcription elongation rate to increase with the rate of transcription initiation.
Tripathi S +3 more
europepmc +2 more sources
Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling [PDF]
Scientific Reports, 2017 HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich DNA.
Xiaodan Zhao +3 more
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Supercoiling DNA optically [PDF]
Proceedings of the National Academy of Sciences, 2019 AbstractCellular DNA is regularly subject to torsional stress during genomic processes, such as transcription and replication, resulting in a range of supercoiled DNA structures.1,2,3 For this reason, methods to prepare and study supercoiled DNA at the single-molecule level are widely used, including magnetic,4,5,6 angular-optical,7,8,9 micro-pipette ...
King, Graeme A. +3 more
openaire +6 more sources
Supercoiling and looping promote DNA base accessibility and coordination among distant sites
Nature Communications, 2021 DNA supercoiling can result in underwinding with negative supercoiling or overwinding with positive supercoiling of the DNA double helix. Here the authors reveal insights into the dynamic relationship between DNA supercoiling-induced sequence-dependent ...
Jonathan M. Fogg +4 more
doaj +1 more source
Supercoiling DNA Locates Mismatches [PDF]
Physical Review Letters, 2017 We present a method of detecting sequence defects by supercoiling DNA with magnetic tweezers. The method is sensitive to a single mismatched base pair in a DNA sequence of several thousand base pairs. We systematically compare DNA molecules with 0 to 16 adjacent mismatches at 1Mmonovalent salt and 3.5 pN force and show that, under these conditions, a ...
Dittmore, Andrew +4 more
openaire +4 more sources
DNA knots and DNA supercoiling [PDF]
Cell Cycle, 2011 Keywords: DNA topoisomerases; DNA topology; DNA structure Reference EPFL-ARTICLE-167094doi:10.4161/cc.10.9.15293View record in Web of Science Record created on 2011-06-24, modified on 2017-05 ...
Guillaume, Witz +2 more
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High-resolution, genome-wide mapping of positive supercoiling in chromosomes
eLife, 2021 Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-dimensional organization of chromosomes. However, there are currently no methods to directly interrogate or map positive supercoils, so their distribution in ...
Monica S Guo +4 more
doaj +1 more source
An Experimental Framework to Examine the Influence of Promoter Architecture and Genomic Context on Gene Expression [PDF]
, 2020 Transcription is a fundamental process of gene expression. Information stored in DNA is transcribed into different types of mobile RNA, which play a role in various essential processes of the cell, e.g. translation.
Klein, Carlo Anton
core +1 more source