Results 21 to 30 of about 1,452,122 (130)
mSystems, 2021 Bacterial gene expression is controlled at multiple levels, with chromosome supercoiling being one of the most global regulators. Global DNA supercoiling is maintained by the orchestrated action of topoisomerases.
Martyna Gongerowska-Jac +8 more
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Effects of DNA Topology on Transcription from rRNA Promoters in Bacillus subtilis
Microorganisms, 2021 The expression of rRNA is one of the most energetically demanding cellular processes and, as such, it must be stringently controlled. Here, we report that DNA topology, i.e., the level of DNA supercoiling, plays a role in the regulation of Bacillus ...
Petra Sudzinová +5 more
doaj +1 more source
Frontiers in Microbiology, 2019 Negative DNA supercoiling allows chromosome condensation and facilitates DNA unwinding, which is required for the occurrence of DNA transaction processes, i.e., DNA replication, transcription and recombination.
Marcin Jan Szafran +4 more
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The Transcriptome of Streptococcus pneumoniae Induced by Local and Global Changes in Supercoiling
Frontiers in Microbiology, 2017 The bacterial chromosome is compacted in a manner optimal for DNA transactions to occur. The degree of compaction results from the level of DNA-supercoiling and the presence of nucleoid-binding proteins.
Adela G. de la Campa +5 more
doaj +1 more source
Chiral theory of DNA supercoiling [PDF]
, 2013 DNA supercoiling is a fundamental biological process occurring in all cells. We developed a theory of braiding (supercoiling) of a pair of DNA molecules that takes into account the contribution of the bending and the electrostatic energy.
Cortini, Ruggero
core +1 more source
Scientific Reports, 2021 Transcription, the first step to gene expression, is a central coordination process in all living matter. Besides a plethora of regulatory mechanisms, the promoter architecture sets the foundation of expression strength, timing and the potential for ...
Carlo A. Klein +3 more
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Supercoiling in DNA and chromatin [PDF]
, 2014 Supercoiling is a fundamental property of DNA and chromatin. It is modulated by polymerase and topoisomerase activities and, through regulated constraint, by DNA/chromatin binding proteins.
Gilbert, N. +3 more
core +1 more source
DNA Supercoiling: an Ancestral Regulator of Gene Expression in Pathogenic Bacteria?
Computational and Structural Biotechnology Journal, 2019 DNA supercoiling acts as a global and ancestral regulator of bacterial gene expression. In this review, we advocate that it plays a pivotal role in host-pathogen interactions by transducing environmental signals to the bacterial chromosome and ...
Shiny Martis B. +4 more
doaj +1 more source
Interaction of the Escherichia coli HU Protein with Various Topological Forms of DNA
Biomolecules, 2021 E. coli histone-like protein HU has been shown to interact with different topological forms of DNA. Using radiolabeled HU, we examine the effects of DNA supercoiling on HU–DNA interactions.
Li Huang, Zhenfeng Zhang, Roger McMacken
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Double-stranded coarse grained model for DNA: applications to supercoiling and denaturation [PDF]
, 2019 DNA supercoiling is the name given to the under or overwinding of the two strands of a DNA double helix. It is of great interest because it is relevant in several crucial biological processes.
Gutiérrez Fosado, Yair Augusto
core +3 more sources