Results 11 to 20 of about 1,452,122 (130)

Profiling DNA supercoiling domains in vivo [PDF]

Genomics Data, 2014
Transitions in DNA structure have the capacity to regulate genes, but have been poorly characterised in eukaryotes due to a lack of appropriate techniques.
Samuel Corless, Catherine Naughton, Nick Gilbert   +2 more
doaj   +2 more sources

Counterintuitive DNA Sequence Dependence in Supercoiling-Induced DNA Melting.

PLoS ONE, 2015
The metabolism of DNA in cells relies on the balance between hybridized double-stranded DNA (dsDNA) and local de-hybridized regions of ssDNA that provide access to binding proteins.
Rifka Vlijm, Jaco V D Torre, Cees Dekker
doaj   +3 more sources

Role of DNA supercoiling in genome structure and regulation [PDF]

, 2014
A principle challenge of modern biology is to understand how the human genome is organised and regulated within a nucleus. The field of chromatin biology has made significant progress in characterising how protein and DNA modifications reflect ...
Corless, Samuel
core   +3 more sources

On the viability of Escherichia coli cells lacking DNA topoisomerase I [PDF]

, 2012
Copyright @ 2012 Stockum et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution,
Lloyd, RG, Lloyd Robert G, Rudolph Christian J, Stockum Anna, Christian J Rudolph, Stockum, A, Anna Stockum, Robert G Lloyd, Rudolph, CJ   +8 more
core   +1 more source

Divergent RNA transcription:A role in promoter unwinding? [PDF]

, 2013
New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction.
Gilbert, Nick, Naughton, Catherine, Corless, Samuel   +2 more
core   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

DNA Supercoiling Regulates the Motility of Campylobacter jejuni and Is Altered by Growth in the Presence of Chicken Mucus

mBio, 2016
Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans, but relatively little is known about the global regulation of virulence factors during infection of chickens or humans.
Claire Shortt, Eoin Scanlan, Amber Hilliard, Chiara E. Cotroneo, Billy Bourke, Tadhg Ó Cróinín   +5 more
doaj   +1 more source

Towards Conformation-Sensitive Inhibition of Gyrase: Implications of Mechanistic Insight for the Identification and Improvement of Inhibitors

Molecules, 2021
Gyrase is a bacterial type IIA topoisomerase that catalyzes negative supercoiling of DNA. The enzyme is essential in bacteria and is a validated drug target in the treatment of bacterial infections.
Dagmar Klostermeier
doaj   +1 more source

The Bacillus subtilis primosomal protein DnaD untwists supercoiled DNA [PDF]

, 2006
The essential Bacillus subtilis DnaD and DnaB proteins have been implicated in the initiation of DNA replication. Recently, DNA remodeling activities associated with both proteins were discovered that could provide a link between global or local nucleoid
Zhang, Wenke, Soultanas, Panos, Allen, Stephanie, Roberts, Clive J.   +3 more
core   +1 more source

A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2. [PDF]

PLoS Genetics, 2012
DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein-DNA and protein-protein interactions is poorly understood.
Andrew D S Cameron, Charles J Dorman
doaj   +1 more source