Results 81 to 90 of about 1,452,122 (130)

Toward a Sensor for DNA Supercoiling

DNA in the cell takes on a double helical structure that is then formed into larger loops, compacting into a supercoil. These supercoils are the result of mechanical torsional forces caused by over or underwound DNA.
Kim, Payton Faith JungIn
core   +4 more sources

Bacterial Nucleoid: Interplay of DNA Demixing and Supercoiling [PDF]

, 2019
International audienceRunning title: DNA demixing and supercoiling. Abstract: This work addresses the question of the interplay of DNA demixing and supercoiling in bacterial cells.
Joyeux, Marc
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, Volume 600, Issue 18, Page 2800-2813, September 2026.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Specific anchoring of large topologically closed DNA for single-molecule protein:DNA interactions

Biophysical Reports
Single-molecule and bulk biophysical approaches to study protein-DNA interactions on surface-immobilized nucleic acid templates typically rely on modifying the ends of linear DNA molecules to enable surface-DNA attachments.
Neville S. Gilhooly, Stephen C. Kowalczykowski   +1 more
doaj   +1 more source

Structural Coupling between RNA Polymerase Composition and DNA Supercoiling in Coordinating Transcription: a Global Role for the Omega Subunit?

mBio, 2011
In growing bacterial cells, the global reorganization of transcription is associated with alterations of RNA polymerase composition and the superhelical density of the DNA.
Marcel Geertz, Andrew Travers, Sanja Mehandziska, Patrick Sobetzko, Sarath Chandra Janga, Nobuo Shimamoto, Georgi Muskhelishvili   +6 more
doaj   +1 more source

Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in Mycobacterium abscessus

mLife, EarlyView.
Shuai Wang, Md Shah Alam, Buhari Yusuf, Jingran Zhang, Ziwen Lu, Xiaofan Zhang, H. M. Adnan Hameed, Mst. Sumaia Khatun, Chunyu Li, Lijie Li, Aleksey A. Vatlin, Aweke M. Belachew, Xirong Tian, Yamin Gao, Cuiting Fang, Rogers P. Zhang, Jun Li, Xinyue Wang, Liqiang Feng, Li Wan, Tianyu Zhang   +20 more
wiley   +1 more source

Single‐Molecule Characterization of Bacterial Factor‐Dependent Transcription Activation by Rob

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Factor‐dependent transcription activation is crucial and involves complex interactions between transcription factors, RNA polymerase, and promoter DNA. Using single‐molecule assays, we show that Rob prebinds RNAP to facilitate promoter search and enhances DNA unwinding and promoter escape.
Yuqiong Zhang, Weijing Han, Jing Shi, Lisha Wang, Cuijuan Teng, Wei Lin, Jun Fan, Shuang Wang   +7 more
wiley   +1 more source

Transcription and Three‐Dimensional Genome Organization: Cause, Consequence, or Coordination?

BioEssays, Volume 48, Issue 9, September 2026.
Transcription and 3D genome organization influence each other across spatial scales. Large‐scale architecture provides a relatively stable framework, while transcription and shared architectural factors refine local chromatin loops and domain boundaries. Specific long‐range interactions between regulatory elements and distal anchors can override domain‐
Dagyeong Yang, Elissa P. Lei
wiley   +1 more source

Exploring the Multitarget Pharmacological Potential of Halogeton sativus Secondary Metabolites: An Integrated Experimental and Computational Approach

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Halogeton sativus is investigated through phytochemical isolation, biological evaluation, molecular dicking, molecular dynamics simulation, and ADMET prediction. The identified metabolites exhibit promising antioxidant, anti‐inflammatory, antimicrobial, and antidiabetic activities, while computational analyses provide mechanistic insights and favorable
Abd Elbasset Tamersit, Soumia Mouffouk, Chaima Mouffouk, Faizul Azam, Rayan A. Mulla, Najeh Kharbatia, Mariusz Jaremko, Abdul‐Hamid Emwas, Nourhene Hamdaoui, Saoudi Mongi, Sara Mouffouk, Waffa Bouafia, Hamada Haba   +12 more
wiley   +1 more source

Fatty Acid Composition of Fixed Oil of Linum strictum and Its Antibiofilm, Anticoagulant, and α‐Amylase Inhibitory Effects–In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Chemical composition, in vitro biological activity and in silico molecular docking of fixed oil of Linum strictum. ABSTRACT The present study investigated the fatty acid composition of Linum strictum seed oil and evaluated its antibacterial, antibiofilm, anticoagulant, and α‐amylase inhibitory activities.
Hayet Edziri, Pooja Bargali, Marwa Melliti, Hasan Aljohi, Mohammad NasserAlkhrayef, Rim Gtari, Marcello Iriti, Ravendra Kumar, Ibrahim O. Alanazi   +8 more
wiley   +1 more source