Results 91 to 100 of about 2,295,017 (227)
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Nonlinear dynamic intertwining of rods with self-contact [PDF]
, 2007 Twisted marine cables on the sea floor can form highly contorted three-dimensional loops that resemble tangles. Such tangles or hockles are topologically equivalent to the plectomenes that form in supercoiled DNA molecules. The dynamic evolution of these
Goyal, Sachin +2 more
core +2 more sources
Supercoil formation in DNA denaturation
Physical Review E, 2009 We generalize the Poland-Scheraga (PS) model to the case of a circular DNA, taking into account the twisting of the two strains around each other. Guided by recent single-molecule experiments on DNA strands, we assume that the torsional stress induced by denaturation enforces formation of supercoils whose writhe absorbs the linking number expelled by ...
KABAKCIOGLU A +2 more
openaire +7 more sources
Dynamic interplay between target search and recognition for a Type I CRISPR-Cas system
Nature Communications, 2023 CRISPR-Cas effector complexes enable the defense against foreign nucleic acids and have recently been exploited as molecular tools for precise genome editing at a target locus. To bind and cleave their target, the CRISPR-Cas effectors have to interrogate
Pierre Aldag +8 more
doaj +1 more source
Nucleation at the DNA supercoiling transition
, 2011 Twisting DNA under a constant applied force reveals a thermally activated transition into a state with a supercoiled structure known as a plectoneme. Using transition state theory, we predict the rate of this plectoneme nucleation to be of order 10^4 Hz.
Bryan C. Daniels +5 more
core +1 more source
A cell engineering strategy to enhance supercoiled plasmid DNA production for gene therapy [PDF]
, 2016 With the recent revival of the promise of plasmid DNA vectors in gene therapy, a novel synthetic biology approach was used to enhance the quantity, (yield), and quality of the plasmid DNA.
Hassan, S, Keshavarz-Moore, E, Ward, J
core +1 more source
Integrative Zoology, EarlyView.Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao +8 more
wiley +1 more source
, 2017 Under supercoiling constraints, naked DNA, such as a large part of bacterial DNA, folds into braided structures called plectonemes. The double-helix can also undergo local structural transitions, leading to the formation of denaturation bubbles and other
A Laio +32 more
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Plant viruses frequently cause severe economic losses in worldwide crop production. Developing broad‐spectrum resistance is the most efficient approach for controlling plant viral diseases. In this work, we found that the 17K protein of barley yellow dwarf viruses (BYDVs), which has multiple functions in viral pathogenesis including acting as ...
Zhaohui Wang +16 more
wiley +1 more source
Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling [PDF]
, 2017 Reverse gyrase is an ATP-dependent topoisomerase that is unique to hyperthermophilic archaea and eubacteria. The only reverse gyrase structure determined to date has revealed the arrangement of the N-terminal helicase domain and the C-terminal ...
del Toro Duany, Yoandris +4 more
core